依法克生及咪唑克生对胍丁胺抗抑郁活性的阻断作用

目的明确胍丁胺抗抑郁作用与咪唑啉受体的关系。方法与结果连续给予CD-1小鼠胍丁胺（10mg/kg,qd,ig）3d,最后一次给药后1h进行强迫游泳或悬尾实验,与盐水对照组相比,胍丁胺可以显著缩短小鼠强迫游泳及悬尾不动时间（P〈0.05）;连续给予依法克生（0.1mg/kg,qd,ip）或咪唑克生（1mg/kg,qd,ip）3d,最后一次给药后30min进行实验,对小鼠强迫游泳及悬尾不动时间均无显著影响（P〉0.05）;但伴随胍丁胺连续给予（15min前）,依法克生（0.1mg/kg）及咪唑克生（1mg/kg）均能逆转胍丁胺缩短小鼠强迫游泳及悬尾不动时间的作用（P〈0.05）。结论胍丁胺对小鼠具有抗抑郁样作用,且与激活咪唑啉受体相关。

The relationship between imidazoline receptors and the antidepressant-like effect of agmatine

Objective To investigate the relationship between imidazoline receptors（I-R）and the antidepressant-like effect of agmatine.Methods and Results The CD-1 mice were treated with agmatine（10 mg/kg,ig）once daily for 3 days.The last dose was given 1 h before the tests.Significant reduction in the duration of immobility was observed in the forced swimming test（FST）and the tail suspension test（TST）.After treatment with efaroxan（0.1 mg/kg,ip）or idazoxan（1 mg/kg,ip）once daily for 3 days,the last dose was given 30 min before the tests.There were no obvious changes in the immobility time.Concomitant pretreatment of efaroxan（0.1 mg/kg,ip）or idazoxan（1 mg/kg,ip）significantly suppressed the decrease in immobility time caused by agmatine in the FST and the TST.Conclusion Agmatine has antidepressant-like effect related to stimulation of I-R.