冠心病患者血小板参数的变化及其临床意义

目的研究血小板参数在冠心病(CHD)和急性心肌梗死(AMI)患者中的变化及其临床意义。方法278例患者分为3组,分别为稳定性心绞痛组(SA)、不稳定性心绞痛(UA)和急性心肌梗死组,非心源性胸痛为对照组。采集所有患者静脉血并用COULTER-750五分类血细胞分析仪检测血小板参数。结果血小板计数在SA组、UA和AMI组、非心源性胸痛对照组间无明显差别。不稳定性心绞痛和急性心肌梗死组与稳定性心绞痛组和非心源性胸痛对照组相比,血小板平均体积(MPV)和血小板分布宽度(PDW)都明显增大。结论血小板体积变大和活化过程可能与冠状动脉血栓形成有关。

Clinical Significance of Platelets Parameters in Patients with Acute Myocardial Infarction and Coronary Heart Disease

Objective To explore the changes of platelet parameters in coronary heart disease （CHD） and acute myocardial infarction （AMI）. Methods A total of 278 cases were divided into three groups including stable angina group （SA）, unstable angina （UA） and acute myocardial infarction group （AMI） and non-cardiac chest pain control group. Venous blood specimens from cases of all groups were analyzed by COULTER- 750 automated blood analyzer. Results There was no significant difference in platelet count among non- cardiac pain group and SA, UA and AMI groups. However, mean platelet volume （MPV） in patients with AMI and UA（9.71 ± 1.73 t） was significantly increased compared with SA group（9.64 ±0.82 t） or non-cardiac chest pain control group（8.55 ± 0.97 fl）. At the same time, patients with AMI and UA（ 18.24 ± 0.61% ） had an increased platelet distribution width （PDW） compared to either SA（17.93± 0.49% ） or non-cardiac chest pain control group（ 16.52 ± 0.58%）. Conclusions The larger, more active platelets might relate to the development of coronary thrombosis.