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肠炎冲剂对溃疡性结肠炎模型大鼠的治疗作用
引用本文:曹永兵,张军东,阎澜,贾鑫明,徐铮,高平挥,姜远英. 肠炎冲剂对溃疡性结肠炎模型大鼠的治疗作用[J]. 药学服务与研究, 2004, 4(2): 114-116
作者姓名:曹永兵  张军东  阎澜  贾鑫明  徐铮  高平挥  姜远英
作者单位:第二军医大学药学院药理学教研室,上海,200433
基金项目:上海中药现代化重大专项基金 (No .0 3DZ195 31)
摘    要:
目的:研究肠炎冲剂对三硝基苯磺酸(TNBS)所致慢性溃疡性结肠炎模型大鼠的治疗作用。方法:TNBS的50%乙醇溶液一次性注人大鼠直肠,造成大鼠的慢性溃疡性结肠炎模型后,连续给药,观察腹泻率、死亡率,分别于连续给药3周及4周后麻醉处死动物,测定组织髓过氧化物酶(MPO)活力。地塞米松为阳性对照药。结果:地塞米松组动物症状减轻,但解剖学检查可见胸腺明显萎缩;连续给予不同剂量的肠炎冲剂药液(给药剂量为11.4、5.7、2.9g生药/kg体重),各剂量组动物腹泻明显缓解,动物死亡率、腹泻率、结肠组织MPO活力明显降低,病理学检查或尸检可见结肠组织溃疡面积明显缩小,水肿缓解,坏死减轻,未见肠壁增厚。肠炎冲剂能显著缓解TNBS所致慢性溃疡性结肠炎症状,且未见地塞米松所致免疫器官萎缩的免疫抑制作用。结论:肠炎冲剂连续给药,对慢性溃疡性结肠炎模型大鼠治疗作用明显,并且未见地塞米松所致严重不良反应,是治疗慢性溃疡性结肠炎的较合适药物。

关 键 词:溃疡性结肠炎 肠炎冲剂 髓过氧化物酶 三硝基苯磺酸
文章编号:1671-2838(2004)02-0114-03
修稿时间:2004-02-24

The efficacy of Changyan granules in treatment of chronic ulcerative colitis model rats
CAO Yong-Bing,ZHANG Jun-Dong,YAN Lan,JIA Xin-Ming,XU Zheng,GAO Ping-Hui,JIANG Yuan-Ying. The efficacy of Changyan granules in treatment of chronic ulcerative colitis model rats[J]. Pharmaceutical Care and Research, 2004, 4(2): 114-116
Authors:CAO Yong-Bing  ZHANG Jun-Dong  YAN Lan  JIA Xin-Ming  XU Zheng  GAO Ping-Hui  JIANG Yuan-Ying
Affiliation:CAO Yong-Bing,ZHANG Jun-Dong,YAN Lan,JIA Xin-Ming,XU Zheng,GAO Ping-Hui,JIANG Yuan-Ying*
Abstract:
Objective: To study the therapeutic effects of Changyan granules on chronic ulcerative colitis model rats. Methods: 2,4,6-Trinitrobenzenesulfonic acid (100 mg/kg) in 50% ethanol was administered to produce colonic ulceration and inflammation in rats. Changyan granules were administered to the model rats for 3 or 4 wk, and the mortality, diarrhea rate and colonic myeloperoxidase(MPO) activity in model rats were examined. Results: Three doses (11.4,5.7,2.9 g crude drug/kg body weight) of Changyan granules were administered for 3 or 4 wk respectively.The mortality,diarrhea rate and colonic MPO activities in rats of 3 groups were decreased obviously as compared with those in the rats of model group.Conclusion: Changyan granules should be studied further as an ideal drug for treating chronic ulcerative colitis.
Keywords:ulcerative colitis  Changyan granules  myeloperoxidase  trinitrobenzenesulfonic acid
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