Adaptation to hypoxia,unlike adaptation to stress,fails to protect the isolated heart from reperfusion after total ischemia (An NMR study) |
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Authors: | L Yu Golubeva S N Dvoryantsev A N Khatkevich I Yu Malyshev F Z Meerson |
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Institution: | (1) Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow;(2) Institute of Experimental Cardiology, Cardiology Research Center, Russian Academy of Medical Sciences, Moscow |
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Abstract: | Effects of adaptation to hypoxia on the contractility of isolated rat hearts and on their levels of ATP and inorganic phosphate
after total ischemia were evaluated. This adaptation failed to render the cardiac energy-supplying system more resistant to
postischemic reperfusion and thus did not accelerate the restoration of cardiac contractility after ischemia. The results
of adaptation to hypoxia were then compared with those of adaptation to stress, which had been shown to bring about a marked
increase in cardiac resistance to postischemic reperfusion. It is concluded that the profound differences noted between the
cardioprotective effects of these two forms of adaptation are due to a much greater accumulation of stabilizing proteins from
the HSP70 family during adaptation to stress.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
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11, pp. 481–484, November, 1995
Presented by N. R. Paleev, Member of the Russian Academy of Medical Sciences |
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Keywords: | stress adaptation heart |
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