食管胃结合部腺癌术后患者预后的相关因素研究

目的 研究食管胃结合部腺癌术后患者预后的相关因素.方法 入选食管胃结合部腺癌患者173例,从手术结束开始随访5年为研究终点,统计患者的1、3、5年生存率和中位生存时间.分析年龄、性别、淋巴结转移、是否化疗、HER-2表达与否等因素与该病的相关性.结果 经过5年随访,食管胃结合部腺癌患者在1、3、5年的生存率分别为87.9％、48.6％、44.5％,中位生存期为38.0月.分别统计和分析患者的各项因素,其中性别(P=0.000)、年龄(P=0.012)、TNM分期(P=0.000)、淋巴结转移(P =0.000)、化疗(P=0.000)、HER-2表达(P=0.000)等因素的差异均具有统计学意义.结论 食管胃结合部腺癌患者术后生存期与性别、年龄、TNM分期、淋巴结转移、是否化疗、HER-2表达均有不同程度的关联,值得进一步研究.

Study on factors related to prognosis of adenocarcinoma in gastroesophageal junction after operation

Objective To study the factors related to the prognosis of patients with adenocarcinoma in gastroesophageal junction after operation. Methods A hundred and seventy three patients diagnosed as adenocarcinoma in gastroesophageal junction were enrolled. The study started from the end of operation, and ended in the fifth year after operation. 1-,3-,5-year survival rates and median survival time were collected. The association of age, gender, lymph node metastasis, chemotherapy, HER-2 expression and the disease was analyzed. Results After 5 years of follow-up, 1-, 3-, 5- year survival rates of patients with adenocarcinoma in gastroesophageal junction were 87.9% ,48.6% ,44.5% , respectively, and the median survival period was 38.0 months. Gender（ P = 0.000 ） , age （ P = 0. 012 ）, TNM staging （ P = O. 000 ）, lymph node metastasis （ P = 0. 000 ）, chemotherapy （ P = 0. 000 ） and the expression of HER-2 （ P = 0. 000 ） were associated with median survival time. Conclusion Gender,age,TNM stage,lymph node metastasis, chemotherapy, and HER-2 expression are all associated with median survival time in patients with adenocarcinoma in gastroesophageal junction.