Comparison of Gd-DTPA-induced signal enhancements in rat brain C6 glioma among different pulse sequences in 3-Tesla magnetic resonance imaging |
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Authors: | Sato H Enmi J Teramoto N Hayashi T Yamamoto A Tsuji T Naito H Iida H |
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Institution: |
a Laboratory for Diagnostic Solutions and Department of Investigative Radiology, Advanced Medical Engineering Center, Research Institute, National Cardiovascular Center, Osaka, Japan;, Diagnostic Imaging Medical Affairs, Medical Affairs, Product Development Department, Bayer Yakuhin, Ltd., Osaka, Japan;, Department of Radiology, Hospital of National Cardiovascular Center, Osaka, Japan |
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Abstract: | Background: T1-shortening contrast media are routinely used in magnetic resonance (MR) examinations for the diagnosis of brain tumors. Although some studies show a benefit of 3 Tesla (T) compared to 1.5T in delineation of brain tumors using contrast media, it is unclear which pulse sequences are optimal.
Purpose: To compare gadopentetate dimeglumine (Gd-DTPA)-induced signal enhancements in rat brain C6 glioma in the thalamus region among different pulse sequences in 3T MR imaging.
Material and Methods: Five rats with a surgically implanted C6 glioma in their thalamus were examined. T1-weighted brain images of the five rats were acquired before and after Gd-DTPA administration (0.1 mmol/kg) using three clinically available pulse sequences (spin echo SE], fast SE FSE], fast spoiled gradient echo FSPGR]) at 3T. Signal enhancement in the glioma (ET) was calculated as the signal intensity after Gd-DTPA administration scaled by that before administration. Pulse sequences were compared using the Tukey-Kramer test.
Results: ET was 1.12±0.05 for FSE, 1.26±0.11 for FSPGR, and 1.20±0.11 for SE. FSPGR showed significantly higher signal enhancement than FSE and comparable enhancement to SE.
Conclusion: FSPGR is superior to FSE and comparable to SE in its ability to delineate rat brain C6 glioma in the thalamus region. |
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Keywords: | Brain contrast agents MR imaging |
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