肺癌中细胞黏附分子-1和L-选择素的表达及临床意义

目的：检测细胞黏附分子-1（ICAM-1）和L-选择素水平，探讨其与肺癌发展、转移、治疗、预后之间的关系。方法：采用免疫组织化学法检测48例肺癌组织ICAM-1的表达，用酶联免疫吸附试验检测48例肺癌患者、18例肺良性病变患者及20例健康志愿者血ICAM-1和L-选择素的浓度。结果：（1）Ⅲ＋IV期肺癌组织和有淋巴结转移者ICAM-1表达分别显著高于Ⅰ＋Ⅱ期和无淋巴结转移者，腺癌组织中ICAM-1表达显著高于鳞癌。（2）肺癌和肺良性病变患者血中ICAM-1和L-选择素水平明显高于健康志愿者，肺癌与肺良性病变患者ICAM-1相比差异有显著性，而L-选择素差异无显著性。Ⅲ＋Ⅳ期显著高于Ⅰ＋Ⅱ期，有转移者与无转移者相比差异均有统计学意义。结论：组织ICAM-1与肺癌的发展和转移有关．检测血ICAM-1和L-选择素含量可以作为肺癌术前诊断及术后效果评估指标之-。

Expressions of intercellular adhesion molecule-1 and L-selection in lung carcinoma and their clinical significance

Objective To investigate the roles of intercellular adhesion molecule-1 （ICAM-1） and L-selectin in the metastasis and progression of lung carcinoma. Methods ICAM- 1 expression was detected by immunohistochemistry in the cancer tissues from 48 patients with lung cancer and serum levels of ICAM-1 and L-selectin were measured using ELISA in 48 patients with lung cancer, 18 with benign lung diseases, and 20 healthy controls. Results ICAM-1 expression was significantly higher in the patients with Ⅲ to Ⅳ disease and lymph node metastasis than those with Ⅰ to Ⅱ disease but no lymph node involvement and it was higher in adenocarcinoma than in squamous cell carcinoma. Serum levels of ICAM-1 and L-selectin were markedly higher in the patients with lung cancer or benign diseases than in the controls while ICAM-1 level was significantly higher in the patients with lung cancer than in those with benign diseases. There were significant differences in levels of ICAM-1 and L-selectin between the patients with Ⅲ to Ⅳ disease or with metastasis and those with Ⅰto Ⅱdisease or with no metastasis. Conclusions ICAM-1 may be associated with the development and metastasis of lung cancer. Serum levels of ICAM-1 and L-selectin can be used as one of the indicators for preoperative diagnosis and postoperative evaluation of lung cancer.[