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TAA方案联合阿米福汀治疗难治性及复发性急性白血病疗效观察
引用本文:万楚成,章正华,夏云金,张霞,龙志国,胡明均,郭仁慈. TAA方案联合阿米福汀治疗难治性及复发性急性白血病疗效观察[J]. 中国临床医学, 2006, 13(5): 778-779
作者姓名:万楚成  章正华  夏云金  张霞  龙志国  胡明均  郭仁慈
作者单位:湖北郧阳医学院附属太和医院血液科,湖北,十堰442000
摘    要:目的:探讨难治性复发性急性白血病(AL)的治疗方法。方法:13例难治性复发性AL用吡喃阿霉素(THP)、安吖啶(AMSA)、阿糖胞苷(Ara-C)组成的TAA方案联合阿米福汀(AMF)方案治疗。THP10mg/d,第1~3天,静滴;AMSA75mg/d,第1~3天,静滴;Ara-C 200mg/d,第1~7天,静滴。AMF 400-800mg/d,第1~5天,静滴。结果:完全缓解(CR)7例(53.8%),部分缓解(PR)3例(23.1%),总有效率为76.9%。结论:阿米福汀对化疗所致机体的损害有保护作用,TAA方案联合AMF是治疗难治性复发性AL的有效方法。

关 键 词:吡喃阿霉素  安吖啶  阿糖胞苷  阿米福汀  难治及复发性急性白血病

Effects of TAA plus Amifostine Regimen on the Treatment of Refractory and Relapsed Acute Leukemia
WAN Chucheng,ZHANG Zhenghua,XIA Yunjin, et al. Effects of TAA plus Amifostine Regimen on the Treatment of Refractory and Relapsed Acute Leukemia[J]. Chinese Journal Of Clinical Medicine, 2006, 13(5): 778-779
Authors:WAN Chucheng  ZHANG Zhenghua  XIA Yunjin   et al
Abstract:Objective:To explore the therapeutic protocol for refractory and relapsed acute leukemia(AL). Methods: 13 patients with refractory and relapsed AL were treated with Amifostine(AMF) and TAA(THP, VP16, AMSA, Ara-C) regimen, which consisted of THP 10 mg/d, VP16 100 mg/d, AMSA 75 mg/d, dayl-3, intravenous infusioa Ara-C200mg/d, dayl -7, AMF400-800mg/d, dayl-7, intravenous infusioa Results: 7 patients(53. 8%) achieved complete remission, 3 pa-tients(23.1%) achieved partial remission, the effective rate was 76. 9%. Conclusion: Amifostine has a protective effect from chemotherapy damage. TAA plus AMF regimen for treatment of refractory and relapsed AL is effective.
Keywords:Pirarubicin   Amsacrine   Cytosine arabinoside   Amifostine   Refractory and relapsed acute leukemia
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