酮替芬治疗猴疟的研究

酮替芬以0.7～20 mg/kg×3天治疗食蟹猴疟证明有明显疗效,无性体与配子体分别于93～102.5 h及102.5～120 h转阴,作用较氯喹慢。对组织期实验证明无效。酮替芬以抗过敏临床治疗剂量0.1 mg/kg合并周效磺胺5 mg/kg连用3天,无性体与配子体分别于79.5 h及153 h消失,表明两药合用有协同作用。使用上述各种剂量未发现嗜睡等不良反应。追踪观察30天,仅酮替芬5 mg/kg×3天治疗2只猴中1只及1 mg/kg×3天治疗的2只猴出现原虫复燃。本研究结果证明,酮替芬是具有抗疟作用的新型化合物,但其对人类疟疾的抗疟作用尚待研究证实。

STUDY ON TREATMENT OF PLASMODIUM CYNOMOLGI INFECTIONS OF MACAQUE WITH KETOTIFEN

Ketotifen 0.7～20 mg/kg×3 days were given orally to P. cynomolgi infected Maecaca mulatta. The asexual parasites and gametocytes in blood were eliminated within 93～102.5 hours and 102.5～120 hours after administration, respectively. When chloroquine 12 mg/kg×3 days was given, however, parasites disappeared in 66 hours. No effect on the tissuestage of this parasite was observed. If ketotifen 0.1mg/kg×3 days was given in combination with sulfadoxin (SDM') 5 mg/kg×3 days, the asexual parasites and gametoeytes disappeared in 79.5 and 153 hours respectively after administration, indicating a synergistic action between these two drugs. No side-effect was observed during the treatments.In 30 days following observation one of the two monkeys treated with 5 mg/kg ×3 days and two monkeys treated with 1 mg/kg×3 days ketotifen recrudescences of blood parasites emerged.The results showed that ketotifen is a new chemical structure type and effective anti-simian-malaria drug, and the observation of its antimalarial effect against human malaria is undertaking.