慢性阻塞性肺疾病急性加重期心肌肌钙蛋白Ⅰ升高的临床意义

目的 探讨慢性阻塞性怖疾病急性加重期住院患者的血清心肌肌钙蛋白Ⅰ(cardiac troponin Ⅰ,cTnI)升高的临床意义.方法 采用前瞻性队列研究方法.测定90例因慢性阻塞性肺疾病急性加重而住院的患者的血清cTnI,同时检查心电图,动脉血气、呼吸困难分级评分等,随访住院期间的临床结局(死亡或存活).结果 90例中有22例患者(24.4%)cTnI升高,并显示呼吸衰竭严重、酸失衡严重及高龄患者更易出现cTnI增高.cTnI升高组的患者病死率显著高于cTnI正常组的患者.结论 cTnI升高可以作为慢性阻塞性肺疾病急性加重期严重程度的评估指标.

Clinical significance of cardiac troponin Ⅰ elevation in acute exacerbation of chronic obstructive pulmonary disease

Objective To assess the value of cardiac troponin I(cTnI)elevation in patients admitted tohospital with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods We examined the records of 90 consecutive patients admitted to hospital for treatment of AECOPD for cTnI.EKG,arterial blood gas analysis,MRCC.Then clinic outcome(death and survival)were followed up.Results cTnI elevation was observed in 22 of 90 cases(24.4%).Patients with raised troponins tended to be older.had lower arteria oxymetry,were more acidotic and more hypercapnoeic.Patients with raised troponins had significantly higher fatality rate.Conclusions Serum cTnI is a senstive index to reflect the severity of AECOPD.