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大豆异黄酮对绝经早期妇女围绝经期症状的改善效应观察
引用本文:叶艳彬,王子莲,苏宜香,陈裕明,卓淑雨,方仕. 大豆异黄酮对绝经早期妇女围绝经期症状的改善效应观察[J]. 营养学报, 2008, 30(2): 203-208
作者姓名:叶艳彬  王子莲  苏宜香  陈裕明  卓淑雨  方仕
作者单位:1. 中山大学附属第一医院,广州,510080
2. 中山大学公共卫生学院,广州,510089
基金项目:广东省广州市科技局科技攻关项目
摘    要:目的确定大豆异黄酮(soybean isoflavone,SI)改善由于雌激素缺失导致的围绝经期症状的生理效应有效剂量,并探讨其可能机制。方法90例45~60岁的绝经早期妇女,随机单盲分为SI84、126mg/(kgbw·d)两个剂量组和安慰剂对照组,每组30人接受追踪观察24w,每4w要求对象记录1w的潮热、出汗次数,做1次围绝经期症状评分(Kuppermanuscore),并在试验前、12w和24w时测定血清雌二醇(E2)、促卵泡生成素(FSH)和黄体生成素(LH)的浓度。结果在试验期间低、高剂量两组的潮热次数(%)分别为57.8±37.4和56.7±26.7和症状评分的下降率(%)分别为44.3±19.1和48.5±27.2,两组间无显著差异,而安慰剂组的潮热次数和症状评分下降率仅为(34.6±46.2)%和(27.8±15.5)%,显著低于前两组。血清E2、FSH和LH在试验各期各组间没有显著差异。结论大豆异黄酮84mg/d可以改善各种围绝经期症状,尤其是潮热、出汗症状,此效应与激素的调节关系不明显。

关 键 词:大豆异黄酮  围绝经期症状  卵巢雌激素  促性腺激素
文章编号:0512-7955(2008)02-0203-06
修稿时间:2007-08-27

EFFECT OF SOY ISOFLAVONES ON MENOPAUSAL SYMPTOMS IN EARLY POSTMENOPAUSAL CHINESE WOMEN
YE Yan-bin,WANG Zi-lian,SU Yi-xiang,CHEN Yu-ming,ZHUO Shu-yu,FANG Shi. EFFECT OF SOY ISOFLAVONES ON MENOPAUSAL SYMPTOMS IN EARLY POSTMENOPAUSAL CHINESE WOMEN[J]. Acta Nutrimenta Sinica, 2008, 30(2): 203-208
Authors:YE Yan-bin  WANG Zi-lian  SU Yi-xiang  CHEN Yu-ming  ZHUO Shu-yu  FANG Shi
Abstract:Objective To study the effect of soy isoflavones(SI) on menopausal symptoms,and its mechanism.Methods Ninety early postmenopausal women were randomly assigned to three treatment groups with daily dosages of 0(placebo),84,126 mg/(kg bw·d) SI(n=30).Hot flash frequency and Kuppermann score and serum 17β-estrodiol(E2),follicle-stimulating hormone(FSH) and luteinizing hormone(LH) were assessed at baseline,12 w and 24 w posttreatment.Results The percent decreases of Kuppermann scores and hot flashes frequency of the two SI treatment groups were 57.8%±37.4%and 44.3%±19.1% in low dose group and(56.7±26.7)% and(48.5±27.2)% in high dose group respectively,significantly higher than those of the placebo group(34.6±46.2)% and(27.8±15.5) %.No significant difference was observed between the two SI groups.The contents of E2,FSH and LH among all groups were insignificantly different.Conclusion A daily dosage of 84 mg soy isoflavones or above could improve menopausal symptoms especially reducing hot flashes frequency and the mechanism seems not associatedwith serum E2,FSH,and LH.
Keywords:soy isoflavones  menopausal symptoms  ovarian hormone  gonadotropins
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