| 谷胱甘肽S-转移酶基因多态性与男性不育 |
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| 引用本文： | 唐开发.谷胱甘肽S-转移酶基因多态性与男性不育[J].中华男科学杂志,2013,19(3):266-269. |
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| 作者姓名： | 唐开发 |
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| 作者单位： | 唐开发 (贵阳医学院附属医院泌尿外科,贵州贵阳550004西安交通大学医学院第一附属医院泌尿外科,陕西西安710061)； |
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| 摘 要： | 男性不育的发生是遗传因素与环境因素相互作用的过程,机体对内外源性化学物质的代谢和解毒能力影响个体对男性不育的易感性。谷胱甘肽S-转移酶(GSTs)属于机体Ⅱ相解毒酶系统,其参与细胞对外源性化学物质和人工合成有机物质解毒的各个生理阶段。研究发现,GSTs基因多态性与男性不育有一定的相关性。在同一地区人群中,GSTs基因多态性对男性不育的易感性具有相似性,也存在不一致性;在不同地区人群中,GSTs基因多态性对男性不育的易感性不一致,也存在相似性。因此,GSTs基因多态性对男性不育患者的易感性在不同人群中存在差异。
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| 关 键 词： | 男性不育 谷胱甘肽S-转移酶 基因多态性 易感性 |
Glutathione S-transferase polymorphisms and male infertility |
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| Abstract: | The pathogenesis of male infertility involves the interactions between environmental and genetic factors.An individual's susceptibility to male infertility is influenced by his internal abilities of metabolizing and detoxicating endogenous and exogenous chemicals.Glutathione-S-transferases(GSTs),such as enzymes,are involved in the cellular detoxication of various physiological and xenobiotic substances.Studies show that the polymorphism of the GSTs gene is correlated with male infertility.GSTs polymorphism-related susceptibilities to male infertility were found similar but with some inconsistencies within the same community,and inconsistent with some similarities among different communities.Therefore,further studies are to be done on the differences in GSTs polymorphism-related susceptibility to male infertility in different communities. |
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| Keywords: | male infertility glutathione-S-transferases polymorphism susceptibility |
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