每日小剂量口服他达拉非治疗无性生活勃起功能障碍患者疗效观察

目的:评估每日小剂量口服他达拉非治疗无性生活勃起功能障碍(ED-NS)患者的疗效。方法:2011年4月至2012年2月门诊符合ED-NS定义患者35例,年龄17～35(25.9±3.9)岁,每日口服他达拉非5 mg治疗3个月,治疗后停药随访3个月。采用北京大学第一医院男科中心设计的SIEF-NS,对患者治疗前、治疗后及随访3个月后SIEF-NS积分进行评估。结果:ED-NS患者治疗前SIEF-NS积分14～38(21.2±5.9)分,治疗3个月后SIEF-NS积分28～55(43.2±7.1)分,随访3个月后SIEF-NS积分26～56(42.1±7.4)分,治疗3个月后及随访3个月后SIEF-NS积分之间无统计学差异,但与治疗前相比明显增加(P<0.05)。结论:每日小剂量口服他达拉非治疗ED-NS患者能够明显改善患者勃起功能,是治疗ED-NS患者的较好选择。

Clinical efficacy of daily low-dose tadalafil on erectile dysfunction-no sexual life

Objective: Erectile dysfunction-no sexual life(ED-NS) is defined as the inability to have enough penile erection hardness and duration so as to have enough confidence in attempting sexual intercourse for more than six months.This study was to investigate the effect of daily low-dose tadalafil on ED-NS.Methods: We treated 35 ED-NS patients aged 17-35(25.9±3.9) years with oral tadalafil at 5 mg qd for 3 months and followed them up for another 3 months after drug withdrawal.We obtained the scores of the patients on Self-estimation Index of Erectile Function-No Sexual Life(SIEF-NS) and compared them before and after medication and at 3 months after drug withdrawal.Results: The patients’ SIEF-NS scores were 43.2±7.1 after medication and 42.1±7.4 at 3 months after drug withdrawal,both significantly higher than 21.2±5.9 before treatment(P<0.05),though there was no significant difference between the former two scores(P>0.05).Conclusion: Daily medication of low-dose tadalafil can significantly improve the erectile function of the patients with ED-NS.