小剂量他达那非治疗骨盆骨折后勃起功能障碍的疗效观察

目的:评估小剂量他达那非每日给药一次治疗骨盆骨折后勃起功能障碍(ED)的疗效。方法:42例骨盆骨折后ED患者依据外伤后时间分为3组,A组:<1个月组、B组:6～24个月组和C组:>24个月组,每天给予5 mg他达那非连续治疗12周,应用IIEF-5评分和"性活动日志"(SEP)评估疗效。结果:共34例患者完成研究,3组均对骨盆骨折后ED有一定的疗效。A组SEP1、SEP2和SEP5平均阳性回答率分别为70%、59%、52%,均显著高于B、C组(P均<0.05);12周后,3组IIEF-5评分分别增加(3.20±2.62)、(1.31±1.70)、(0.91±1.87)分,A组显著高于B、C组(P均<0.05)。结论:小剂量他达那非每日给药一次对骨盆骨折后ED有较好的康复作用,外伤后越早使用其疗效越好。

Low-dose tadalafil for erectile dysfunction following pelvic fracture-induced urethral injury:Clinical observation of 42 cases

Objective: To evaluate the efficacy of daily low-dose tadalafil in the treatment of erectile dysfunction(ED) following pelvic fracture-induced urethral injury(PFUI).Methods: Based on the length of time between pelvic fracture and the patients’ clinic visit,we divided 42 PFUI-caused ED patients into groups A(<1 month),B(6-24 months) and C(>24 months).We treated them with tadalafil at 5 mg daily for 12 weeks consecutively,followed by evaluation of the therapeutic effect using IIEF-5 questionnaire and Sexual Encounter Profile(SEP) diaries.Results: Thirty-four patients(83.3%) completed the investigation and all responded well to tadalafil medication.Group A showed significant differences from B and C in the increase of IIEF-5 scores and the positive rate of SEP.Conclusion: Daily low-dose tadalafil helps penile rehabilitation in ED patients following PFUI,and the earlier the medication is initiated,the better the effect will be.