277例梅毒患者规范驱梅后血清TRUST转阴影响因素分析

目的探索梅毒患者血清TRUST转归的影响因素。方法对2011年4月—2014年6月深圳市南山区慢性病防治院首次确诊及治疗并随访24个月的277例梅毒患者进行调查,使用Cox比例风险回归模型分析梅毒患者血清TRUST转归的影响因素。结果不同性别、年龄、婚姻、文化程度和是否合并HIV感染的梅毒患者血清TRUST转阴情况之间差异均无统计学意义(P0.05);不同诊断分期和初始TRUST滴度梅毒患者转阴情况之间差异均有统计学意义(P0.05)。Cox比例风险回归模型分析结果显示:一期梅毒患者比隐性梅毒患者血清TRUST更易转阴(RR=3.04,95%CI:1.95~4.73;P0.05),初始TRUST滴度≤1∶8患者比滴度1∶8患者血清TRUST更易转阴(RR=2.34,95%CI:1.40~3.91;P0.05)。结论梅毒的诊断分期和初始血清TRUST滴度是影响梅毒预后的独立影响因素。

Influencing factors of TRUST outcomes in 277 syphilis patients with standard treatment

Objective To explore the influencing factors of the toluidine red unheated serum test (TRUST) in syphilis patients with the standard treatment.Methods From April 2011 to June 2014,277 firstly confirmed syphilis patients who received the standard treatment and followed up for 24 months by Shenzhen Nanshan Chronic Disease Prevention Hospital were investigated.The Cox proportional hazard regression model was used to analyze the influencing factors of the TRUST outcomes.Results There were no significance differences between/among genders,ages,marriages,and being HIV infection or not in the TRUST negative outcomes (P＞0.05),however,the different diagnosis period and the initial TRUST titer had significant differences (P＜0.05).The Cox proportional hazard regression model showed that TRUST of the primary syphilis patients turned to be negative more easily than that of the latent syphilis patients (RR=3.04,95％CI:1.95-4.73;P＜0.05),and the patients with the initial TRUST titer≤1∶ 8 were more likely to become negative than the ones with the titer＞1∶ 8 significantly (RR=2.34,95％CI:1.40-3.91;P＜0.05).Conclusion The syphilis diagnostic stage and initial TRUST titer are the independent influencing factors of syphilis prognosis.