| 间日疟控制和消除的挑战及其对策研究进展 |
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| 引用本文： | 董新炜,许建卫.间日疟控制和消除的挑战及其对策研究进展[J].中国热带医学,2017(10):1047-1051. |
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| 作者姓名： | 董新炜 许建卫 |
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| 作者单位： | 1. 大理大学病原与媒介生物研究所,云南大理,671000;2. 大理大学病原与媒介生物研究所,云南大理671000;云南省寄生虫病防治所,云南普洱665000 |
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| 基金项目： | 国家自然科学基金资助项目(81560543) |
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| 摘 要： | 间日疟地理分布广,是现今疟疾控制和消除的最大挑战之一。本文通过查阅各类相关数据库,综述了间日疟控制和消除的挑战及其应对策略研究进展。各类来源的研究资料显示间日疟更易于传播,媒介控制措施效果差;无症状和亚显微镜检测密度带虫者比例高,常规检测困难;磷酸伯氨喹啉(唯一根治药)安全性低。为应对这些挑战,现正在从传播阻断、实验诊断、抗疟药物和方案等方面开展研究。
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| 关 键 词： | 间日疟 消除疟疾 G6PD缺乏 根治 挑战 |
The challenges and progress update on control and elimination of Plasmodium vivax malaria |
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| DONG Xinwei,XU Jianwei.The challenges and progress update on control and elimination of Plasmodium vivax malaria[J].China Tropical Medicine,2017(10):1047-1051. |
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| Authors: | DONG Xinwei XU Jianwei |
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| Abstract: | Plnsmodium vivax has the largest geographic distribution among malaria parasites.Control and elimination of vivax malaria is one of the biggest challenges at present.This paper reviewed challenges and progress updates on control and elimination of Plasmodium vivax malaria through collecting various resources.These data show that Plasmodium vivax is more transmissible and difficult to interrupt transmission,more undetectable by routine tests due to a high proportion of individuals with asymptomatic and submicroscopic parasite density,and low safety of primaquine (only available drug for radical cure).The researches updated are strategies of interrupting transmission,laboratory test diagnosis and development of antimalarial drugs and treatment regimens. |
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| Keywords: | Plasmodium vivax malaria elimination G6PD deficiency radical cure treatment challenges |
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