左氧氟沙星对初治涂阳肺结核疗效分析

目的探讨采用左氧氟沙星对初治涂阳肺结核的疗效。方法将2016年1月—5月在结核病防治科登记治疗的120例初治涂阳肺结核患者随机分为3组,分别以A组(左氧氟沙星组)4HRZEL/2HR,B组(强化期延长方案组)4HRZE/2HR,C组(标准方案组)2HRZE/4HR方案进行6个月抗结核治疗。结果 3组2月末痰培养阴转率分别为91.7%,77.1%,82.9%,5月末痰培养阴转率分别为100.0%,91.4%,85.7%,6月末痰培养阴转率分别为100.0%,94.3%,88.6%,3组间痰菌阴转率差异无统计学意义(P0.05)。3组6月末病灶明显吸收率分别为80.6%,54.3%,45.7%,A组明显高于B组和C组(P0.05)。3组6月空洞闭合率分别为95.0%,75.0%,62.5%,A组高于C组(P0.05),但与B组比较差异无统计学意义(P=0.077)。结论 4HRZEL/2HR治疗方案可提高初治涂阳肺结核治愈率和病灶吸收率,但仍需进一步研究。

Levofloxacin on primary smear positive pulmonary tuberculosis

Objective To investigate the curative effect of different chemotherapy regimens in the treatment of newly diagnosed smear positive pulmonary tuberculosis.Methods A total of 120 patients with newly diagnosed smear positive pulmonary tuberculosis were randomly divided into 3 groups from January 2016 to May 2016, group A (levofloxacin group) 4HRZEL/2HR, group B (extended period group) 4HRZE/2HR, group C (standard group) 2HRZE/4HR with 6 months of anti tuberculosis scheme.Results Three groups of at the end of two months sputum culture negative conversion rate were 91.7％, 77.1％, 82.9％, at the end of five months sputum culture negative conversion rate were 100.0％, 91.4％, 85.7％, at the end of six months sputum culture negative conversion rate were 100.0％, 94.3％, 88.6％.There was no significant difference between the three groups in sputum negative conversion rate (P＞0.05).Three groups at the end of six months, the absorption rate of lesions was 80.6％, 54.3％, 45.7％, group A was significantly higher than that of group B and group C (P＜0.05).The closure rate of the three groups was 95.0％, 75.0％, 62.5％ at the end of six months, group A was higher than group C (P＜0.05).However, there was no significant difference between the group B and group A (P=0.077).Conclusion 4HRZEL/2HR treatment can improve the cure rate and the absorption rate of smear positive pulmonary tuberculosis, but it still needs further research.