7098例泌尿生殖道标本支原体感染状况及药敏结果分析

目的了解近年来长沙地区泌尿生殖道支原体感染状况及常用药物敏感性的特征,为临床诊疗及合理用药提供依据。方法采集2016年6月—2017年2月门诊患者的泌尿生殖道标本,进行解脲脲原体(Uu)和人型支原体(Mh)培养及药敏试验,分析培养及药敏结果。结果共收集7 098例泌尿生殖道支原体标本,共检出阳性标本2 123例,总阳性率29.9%。女性患者感染率32.9%,男性患者感染率18.5%,不同性别患者感染率差异有统计学意义(P0.05)。不同年龄组间感染率差异有统计学意义(P0.05),48~57岁组感染率最高,≥68岁组感染率最低。不同型别以Uu单纯感染为主,占82.0%,其次是Uu+Mh混合感染,占14.4%。不同感染型别对常用药物存在不同程度的耐药,Uu+Mh混合感染的耐药率最高。结论近年来长沙地区泌尿生殖道支原体以Uu单纯感染为主,美满霉素、强力霉素和交沙霉素对不同型别支原体感染有较好的敏感性。

Urogenital tract Mycoplasma infection status and drug sensitivity of 7 098 cases

Objective To investigate the conditions of urogenital tract Mycoplasma infection and drug sensitivity in recent years in Changsha region,so as to provide the evidence for the rational use of antimicrobial drugs in clinics.Methods From June 2016 to February 2017,the urogenital tract specimens of outpatients were collected to cultivate Ureaplasma urealytium (Uu) and Mycoplasma hominis (Mh).The positive specimens and results of drug sensitivity tests were analyzed.Results Among 7 089 inspected specimens,2 123 were positive with the rate of 29.9％.The infection rate of the females (32.9％) was significantly higher than that of the males (18.5％),and there was a significant difference between the different genders (P＜0.05).There was a significant difference among different age groups in Mycoplasma infection rates (P＜ 0.05),and the patients between 48 and 57 years old presented the highest infection rate,and the individuals older than 68 years presented the lowest.The single infection of Uu was the main form (82.0％) in the infected specimens,and the multi-infections of Uu and Mh amounted for 14.4％.The patients with different infection types displayed different degrees of resistance to commonly used drugs.The commonly used dug sensitivity tests showed that the drug resistance rate of mixed infections of Uu and Mh was significantly higher than that of Uu or Mh infection.Conclusions The single infection of Uu is the main form of urogenital tract Mycoplasma infection in Changsha region in recent years.The infection rate of the females is significantly higher than that of the males.Minocycline,doxycycline and josamycine have better sensitivity in treatment of different kinds of Mycoplasma infection.