| 消化性溃疡患者体内一氧化氮含量测定及其意义 |
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| 引用本文： | 傅万炎,马高峰,何小飞,余启元,王四玲,魏敏,周宏星. 消化性溃疡患者体内一氧化氮含量测定及其意义[J]. 咸宁医学院学报, 1997, 0(3) |
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| 作者姓名： | 傅万炎 马高峰 何小飞 余启元 王四玲 魏敏 周宏星 |
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| 作者单位： | 咸宁医学院附属第一医院内科 |
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| 摘 要： | 为探讨一氧化氮与消化性溃疡的关系,用镉还原层析加显色法对32例消化性溃疡(PU)患者和12例正常人血浆、胃液、胃粘膜中NO_2/NO_3含量进行了测定。结果发现:幽门螺杆菌(Hp)阳性PU组血浆、胃粘膜中NO_2/NO_3含量显著高于正常组;Hp阴性PU组血浆、胃粘膜NO_2/NO_3含量显著低于正常组。各组胃液NO_2/NO_3含量无显著性差异。提示:一氧化氮与PU的发病机制有关,且在Hp相关性PU与非相关性PU的病理生理过程中可能存在着不同的一氧化氮机制。
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| 关 键 词： | 消化性溃疡 一氧化氮 幽门螺杆菌 |
The Determination of Nitric Oxide in Body and Their Significance in Patients With Peptic Ulcer |
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| Fu Wanyian Ma Gaofeng He Xiaofei et al. The Determination of Nitric Oxide in Body and Their Significance in Patients With Peptic Ulcer[J]. Journal of Xianning Medical College, 1997, 0(3) |
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| Authors: | Fu Wanyian Ma Gaofeng He Xiaofei et al |
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| Affiliation: | Fu Wanyian Ma Gaofeng He Xiaofei et al Department of Gastroenterology,the First Affiliated Hospital |
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| Abstract: | In order to study the relationship between nitric oxide and peptic ulcer (PU), nitrite/nitrate contents in plasma, gastric juice and gastric mucosa were determined with Greiss method in 32 patients with peptic ulcer and 12 normal controls. It was found that the nitrite/nitrate contents in plasma and gastric mucosa of Hp - positive PU groups were both significantly increased (P < 0. 05 ), compared with normal controls; the nitrite/nitrate contents in plasma and gastric mucosa of Hp - negative PU groups were both obviously decreased (P<0.01), compared with normal controls. However, the nitrite/nitrate contents in gastric juice of all groups has no significant difference. This suggests that nitric oxide is involved in pathogenesis of peptic ulcer, and that NO mechanism in Hp-associated PU may not be the same as that in non - Hp - associated PU. |
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| Keywords: | Peptic ulcer Nitric oxide Helicobacter pylori |
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