Vav3与MMP-2在人胃癌组织中的表达及临床意义

目的 探讨Vav3与MMP-2蛋白在胃癌中的表达及其与临床病理特征之间的关系。方法 免疫组化SP法检测Vav3与MMP-2在91例胃癌组织中的表达情况，并分析两者与临床病理特征之间的关系。结果 胃癌组织中的Vav3、MMP-2蛋白阳性表达率分别为57.1％（52／91）和68.1％（62／91），均高于癌旁组织的30.5％（25／82）和25.6％（21／82），差异有统计学意义（P＜0.05）。Vav3表达与TNM分期、淋巴结是否转移以及血管浸润情况有关（P＜0.05）；MMP-2表达与淋巴结是否转移、TNM分期有关（P＜0.05）。Vav3蛋白与MMP-2蛋白表达呈正相关（r=0.313，P=0.003）。结论 Vav3蛋白在胃癌中高表达，与患者TNM分期、淋巴结转移以及血管浸润有关，且与MMP-2蛋白表达呈正相关，提示Vav3蛋白可能参与胃癌侵袭与转移通路。

Expression and clinical significance of Vav3 and MMP-2 in human gastric cancer

Objective To investigate the expression of Vav3 and MMP-2 and its association with clinicopathological features in human gastric cancer. Methods The expression of Vav3 and MMP-2 in gastric cancer was detected by immunohistochemistry， and the relationship with clinicopathological features was analyzed. Results The positive expression rate of Vav3 and MMP-2 in gastric cancer were 57.1％（52／91） and 68.1％（62／91）， which were significantly higher than those in pericarcinoma tissues（30.5％，25／82； 25.6％，21／82）. Expression of Vav3 was closely correlated with TNM stage， lymphatic metastasis and vascular infiltration（P＜0.05）； Expression of MMP-2 was closely correlated with TNM stage and lymph node metastasis（P＜0.05）. The positive correlation was found between Vav3 and MMP-2 in gastric cancer（r=0.313， P=0.003）. Conclusion Vav3 and MMP-2 were high expressed in gastric cancer and the correlation between them was positive correlation. The expression of Vav3 protein may be involved in tumor invasion and metastasis event.