麻黄碱对单胺氧化酶活性的影响

麻黄碱于体外抑制单胺氧化酶的最低有效浓度为20毫克分子,其抑制强度約为异丙异烟肼的1/20。于体內不論麻黄碱4毫克/公斤一次,或每隔半小时一次,共五次,总量为20毫克/公斤,对单胺氧化酶都无影响。

THE INFLUENCE OF EPHEDRINE ON THE ACTIVITY OF AMINEOXIDASE

The inhibitory activity of ephedrine on the amineoxidase of rat liver was determined in vitro and in vivo. The minimal inhibitory concentration of ephedrine in vitro was found to be 20 mM and this inhibitory activity of ephedrine on this enzyme was about one twentieth of that of iproniazid. In vivo, however, ephedrine did not produce any effect on the amineoxidase either in a single dose of 4 mg/kg or in an accumulated dose of 20 mg/kg given in 5 equal fractions at 30 min intervals.