| 人甲状旁腺组织体外培养及高磷的影响 |
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| 引用本文： | 王小兵,王笑云,毛慧娟,曾鸣,孙彬,赵秀芬.人甲状旁腺组织体外培养及高磷的影响[J].中华内分泌代谢杂志,2006,22(1):79-80. |
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| 作者姓名： | 王小兵 王笑云 毛慧娟 曾鸣 孙彬 赵秀芬 |
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| 作者单位： | 1. 江苏省姜堰市人民医院肾内科,225500
2. 210029,南京医科大学第一临床医学院肾科 |
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| 摘 要： | RT—PCR检测人甲状旁腺有无磷钠转运体Pit-1mRNA表达；高磷、膦甲酸钠（PFA）刺激体外培养的人甲状旁腺组织，观察PTH分泌量的变化。发现甲状旁腺表达Pit-1；高磷通过作用于Pit-1促进PTH分泌，而PFA抑制其分泌。
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| 关 键 词： | 磷 甲状旁腺 膦甲酸钠 磷钠转运体 |
| 收稿时间： | 2004-09-13 |
| 修稿时间： | 2004年9月13日 |
Cultivation of human parathyroid tissue and effect of high phosphate in vitro |
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| WANG Xiao-bing,WANG Xiao-yun,MAO hui-juan,ZENG Ming,SUN Bin,ZHAO Xiu-fen.Cultivation of human parathyroid tissue and effect of high phosphate in vitro[J].Chinese Journal of Endocrinology and Metabolism,2006,22(1):79-80. |
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| Authors: | WANG Xiao-bing WANG Xiao-yun MAO hui-juan ZENG Ming SUN Bin ZHAO Xiu-fen |
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| Institution: | Department of Nephrology, First Clinical Medical College, Nanjing Medical University ,Nanjing 210029 |
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| Abstract: | RT-PCR was used to identify the expression of Na/P cotransporter Pit-1 in human parathyroid tissue. The change of PTH secretion was observed in parathyroid in vitro exposed to high concentration of phosphate and phosphonoformic acid (PFA). It was found that Pit-1 expressed in parathyroid tissue and high concentration of phosphate induced PTH secretion via Na/P cotransporter Pit-1, but PFA inhibited. |
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| Keywords: | Phosphorus Parathyroid glands Phosphonoformic acid Na/P cotransporter |
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