| Synthesis of Cardiotonic Agent Imidazopyridine |
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| 作者姓名： | 孙常晟 章迪华 杜德宏 江贞仪 刘世霆 |
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| 作者单位： | Department of Pharmaceutical Chemistry Faculty of Pharmacy，Second Military Medical College，Shanghai，Department of Pharmaceutical Chemistry，Faculty of Pharmacy，Second Military Medical College，Shanghai，Department of Pharmaceutical Chemistry，Faculty of Pharmacy，Second Military Medical College，Shanghai，Department of Pharmaceutical Chemistry，Faculty of Pharmacy，Second Military Medical College，Shanghai，Department of Pharmaceutical Chemistry，Faculty of Pharmacy，Second Military Medical College，Shanghai |
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| 摘 要： | A new orally active non-glycosidic,non-adrenergic cardiotonicagent,2-(2-methoxy-4-methylsulfinyl)phenyl]-1H-imidazo4,5-b]pyridine(AR-L115BS)has been synthesized.The two key interme-diates,2,3-diaminopyridine and 2-methoxy-4-methyl-mercaptoben-zoic acid were prepared according to the routes submitted by Foxand Zipp respectively.The approaches were improved to adaptlarge scale laboratory preparation.The structure of the end productwas proved by elemental analysis,mass spectra,~1H nuclear magneticresonance spectra and infrared spectra.
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Synthesis of Cardiotonic Agent Imidazopyridine |
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| Sun Changsheng Zhang Dihua Du Dehong Jiang Zhenyi Liu Shiting.Synthesis of Cardiotonic Agent Imidazopyridine[J].Journal of Medical Colleges of PLA(China),1986(3). |
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| Authors: | Sun Changsheng Zhang Dihua Du Dehong Jiang Zhenyi Liu Shiting |
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| Institution: | Sun Changsheng Zhang Dihua Du Dehong Jiang Zhenyi Liu Shiting Department of Pharmaceutical Chemistry,Faculty of Pharmacy,Second Military Medical College,Shanghai |
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| Abstract: | A new orally active non-glycosidic,non-adrenergic cardiotonic agent,2-(2-methoxy-4-methylsulfinyl)phenyl]-1H-imidazo4,5-b] pyridine(AR-L115BS)has been synthesized.The two key interme- diates,2,3-diaminopyridine and 2-methoxy-4-methyl-mercaptoben- zoic acid were prepared according to the routes submitted by Fox and Zipp respectively.The approaches were improved to adapt large scale laboratory preparation.The structure of the end product was proved by elemental analysis,mass spectra,~1H nuclear magnetic resonance spectra and infrared spectra. |
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| Keywords: | cardiotonic agents imidazopyridine synthesis |
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