虫草多糖对小鼠化学性肝损伤的保护作用

目的观察虫草多糖(CP)对小鼠急性化学性肝损伤的保护作用.方法分别采用四氯化碳(CCl4)和D-氨基半乳糖(D-galactosamine, D-GalN)诱导小鼠急性化学性肝损伤,比色法测定血清中丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)的含量、肝匀浆中超氧歧化酶(SOD)活力以及丙二醛(MDA)浓度,并作肝组织切片病理观察.结果虫草多糖(125、250、500 mg/kg)ig 给药明显降低CCl4和D-GaLN诱导的化学性肝损伤后小鼠血清中升高的ALT和AST水平,抑制肝匀浆中上升的MDA水平和升高过低的SOD活性.病理检查结果显示有明显的保肝作用.结论虫草多糖对小鼠急性化学性肝损伤有一定的保护作用.

Protective action of cordyceps polysaccharides on chemical liver injury in mice

Objective To observe the protective action of cordyceps polysaccharides(CP) on chemical liver injury in mice. Methods The carbon tetrachloride ( CCl 4 ) and the D-galactosamine(D-GalN) were used for mice chemical liver injury, ALT, AST levels in serum, the activity of SOD and the concentration of MDA in liver homogenates were examined and the liver pathology was observed. Results The experiment showed that the cordyceps polysaccharides(125,250,500 mg/kg,ig)could reduce the rising ALT?AST level in serum of mice with liver injury induced by CCl 4 and D-GalN , inhabit the rising MDA and inhance the activity of SOD in liver,the pathology cut section also showed obviously protective effect. Conclusions The cordyceps polysaccharides has protective action for chemical liver injury to a certain extent.