Effects of levosimendan on circulating pro-inflammatory cytokines and soluble apoptosis mediators in patients with decompensated advanced heart failure |
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| Authors: | Parissis John T Adamopoulos Stamatis Antoniades Charalambos Kostakis George Rigas Antonios Kyrzopoulos Stamos Iliodromitis Efstathios Kremastinos Dimitrios |
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| Affiliation: | Second Department of Cardiology, Amalia Fleming Hospital, Athens, Greece. j.parissis@yahoo.com |
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| Abstract: | This randomized, placebo-controlled trial showed that levosimendan administration causes a significant reduction of circulating proinflammatory cytokine interleukin-6 and soluble apoptosis mediators, such as soluble Fas and Fas ligand in patients with decompensated heart failure. These immunomodulatory effects may lead to improvement of symptoms and echocardiographic markers of cardiac contractile performance in these patients. |
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