血浆同型半胱氨酸高敏C反应蛋白与不稳定性心绞痛的相关性研究

目的:探讨不稳定性心绞痛患者与血浆同型半胱氨酸(Hcy)、高敏C反应蛋白(hs-CRP)浓度的相关性。方法:不稳定性心绞痛伴2型糖尿病患者40例(DM组)及同期住院不伴糖尿病的不稳定性心绞痛患者40例(非DM组)为研究对象,另选择同期住院的稳定性心绞痛40例为对照组。受检者检测Hcy、hs-CRP浓度,均经正规治疗并随访6个月,观察再发心绞痛、急性心肌梗死(AMI)、心脏性死亡的发生率。分组比较标志物浓度及其与患者预后的关系。结果:DM组、非DM组血浆Hcy、hs-CRP浓度均较对照组高(P<0.01),另DM组二者浓度均较非DM组高(P<0.05)。DM组与非DM组血浆Hcy和血清hs-CRP浓度呈正相关。在随访中,DM组、非DM组再发心绞痛、AMI、心脏性死亡的发生率均高于对照组(P<0.01)。而DM组高于非DM组(P<0.05)。结论:血浆同型半胱氨酸(Hcy)、高敏C反应蛋白(hs-CRP)浓度是评价不稳定性心绞痛患者预后的重要指标且与患者病情呈正相关。

The Investigation on. the Relationship between Plasma Homocystcinc C- reactive Protein and Unstable Angina

Objective:To explore the relationship between unstable angina and the levels of plasma homocystcinc(Hcy) and high sensitive C-reactive Protein(hs-CRP).Methods: observing and comparing 3 groups of patients who are cared in the hospital at the same time.DM Group-40 patients with unstable angina and type 2 diabetes mellitus and Non-DM group-40 unstable angina patients without diabetes mellitus are studied and compared with the third group-40 patients with stable angina.All the subjects have been systematically treated and monitored for six months afterwards.The levels of Hcy and hs-CRP of the subjects have been measured and the ratio of angina re-occurring,acute myocardial(AMI) and cardiogenic death have been counted.Comparing Hcy and hs-CRP levels of patients in different groups and the analyzing their relationship with the patients recovering.Result: Hcy and hs-CRP levels of patients in DM group and Non-DM group are higher than that of patients in the third group(P<0.01);Hcy and hs-CRP levels of patients in DM group are higher than that of patients in Non-DM group(P<0.05);there is a positive correlation between the level of Hcy and the level of hs-CRP of patients' in DM group and Non-DM group.In the after-treatment visits,the ratio of patients in DM group and Non-DM group having angina re-occurring,acute myocardial(AMI) and cardiogenic death is higher than that of patients in the third group.Conclusion: the levels of Hcy and hs-CRP are key indicators in evaluating unstable angina patients' after-treatment conditions and have a positive correlation with patients' disease.