Representativeness of the Framingham risk model for coronary heart disease mortality: a comparison with a national cohort study |
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| Authors: | P E Leaverton P D Sorlie J C Kleinman A L Dannenberg L Ingster-Moore W B Kannel J C Cornoni-Huntley |
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| Affiliation: | 1. Department of Epidemiology and Biostatistics, University of South Florida College of Public Health, Tampa, Florida, U.S.A.;2. Epidemiology and Biometry Program, Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Maryland, U.S.A.;3. Division of Analysis, National Center for Health Statistics, Hyattsville, Maryland, U.S.A.;4. Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts, U.S.A.;5. Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland, U.S.A.;1. From the Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China;2. Beijing Key Laboratory of Nasal Diseases, Beijing Tongren Hospital, Capital Medical University, Beijing, China;1. Skull Base Multi-disciplinary Unit, Department of Neurosurgery B, Neurological Hospital Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France;2. Department of Anatomy, University of Lyon 1, Lyon, France;3. University of Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, Lyon, France;4. Department of Radiology, Lyon Sud Hospital, Hospices Civils de Lyon, Lyon, France;1. Department of Biophysics, University of Delhi South Campus, New Delhi, 110021, India;2. Department of Life Science, School of Sciences, Indira Gandhi National Open University, New Delhi, 110068, India;3. Centre for Information Services and High Performance Computing (ZIH), Technical University Dresden, Germany;1. Department of Radiology, Jinshan Hospital of Fudan University, Shanghai Medical College, Shanghai 201508, China;2. Department of Radiology, Eye and ENT Hospital of Fudan University, Shanghai Medical College, Shanghai 200031, China;3. Department of Radiology, Shanghai Ninth People''s Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 200011, China |
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| Abstract: | The Framingham Heart Study has been the foundation upon which several national policies regarding risk factors for coronary heart disease mortality are based. The NHANES I Epidemiologic Followup Study is the first national cohort study based upon a comprehensive medical examination of a probability sample of United States adults. The average follow-up time was 10 years. This study afforded an opportunity to evaluate the generalizability of the Framingham risk model, using systolic blood pressure, total cholesterol, and cigarette smoking, to the U.S. population with respect to predicting death from coronary heart disease. The Framingham model predicts remarkably well for this national sample. The major risk factors for coronary heart disease mortality described in previous Framingham analyses are applicable to the United States white adult population. |
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