系统性红斑狼疮合并带状疱疹临床分析

目的：分析SLE患者的带状疱疹临床特点，以及探讨SLE患者的病情活动和治疗对发生带状疱疹的影响。方法：临床回顾1991－2000年住院合并有带状疱疹的SLE患者临床特点，对带状疱疹发生的一些可能的相关因素行分析比较和χ^2检验。结果：这一组患者中，带状疱疹的发生率为9．80％，高于同期全部住院患者带状疱疹的发生率，临床症状相对较重；带状疱疹的发生率在病情活动、应用糖皮质激素及环磷酰胺治疗时较高。结论：SLE容易合并带状疱疹；病情相对较重；病情活动、应用糖皮质激素及环磷酰胺治疗时带状疱疹的发生率较高。

Clinical analysis of herpes zoster in patients with systemic lupus erythematosus

Objective: To analysis clinical features of herpes zoster in patients with systemic lupus erythematosus (SLE) and to determine the risk factors associated with the development of herpes zoster in patients with SLE. Method:The clinical data on the hospitalized patients with SLE complicated by herpes zoster from 1991 to 2000 were reviewed, and the factors associated with the development of herpes zoster were analyzed.Results:The incidence of herpes zoster was 9.80%, which was higher in this group of patients than in all hospitalized patients in the same period of time. The incidence of herpes zoster was higher when SLE was active and when SLE patients were treated with corticostercids and immunosuppressive therapy, compared with control groups. Conclusion :The occurrence of herpes zoster in patients with SLE is not uncommon. Severity of the disease, treatment with corticostercids and cyclophosphamide therapy, and being active may be risk factors for the development of herpes zoster in the patients with SLE.