| 非索非那定的微生物转化制备 |
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| 引用本文： | 刘雪峰,冯军,程晴华,赵文杰. 非索非那定的微生物转化制备[J]. 中国医药工业杂志, 2006, 37(7): 449-451 |
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| 作者姓名： | 刘雪峰 冯军 程晴华 赵文杰 |
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| 作者单位： | 上海医药工业研究院,上海,200040 |
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| 摘 要： | 研究了以普拉特链霉菌SIPI-76微生物转化特非那定为非索非那定的条件。考察碳源、氮源等培养基成分，底物的加入浓度、时间，生长细胞培养时的pH、温度、溶氧等参数对转化的影响。表明在优化条件下转化率达到90％。
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| 关 键 词： | 非索非那定 特非那定 微生物转化 |
| 文章编号： | 1001-8255（2006）07-0449-03 |
| 收稿时间： | 2005-06-15 |
| 修稿时间： | 2005-06-15 |
Preparation of Fexofenadine by Microbial Transformation |
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| LIU Xue-Feng,FENG Jun,CHENG Qing-Hua,ZHAO Wen-Jie. Preparation of Fexofenadine by Microbial Transformation[J]. , 2006, 37(7): 449-451 |
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| Authors: | LIU Xue-Feng FENG Jun CHENG Qing-Hua ZHAO Wen-Jie |
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| Affiliation: | Shanghai Institute of Pharmaceutical Industry, Shanghai 200040 |
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| Abstract: | The microbial transformation conditions for preparation of fexofenadine from terfenadine by S. platensis SIPI-76 were studied. The factors affecting on the transformation were investigated, such as carbon and nitrogen source of medium, addition time and concentration of the substrate, pH, temperature, dissolved oxygen during cell growth. Under the optimal conditions, the transformation efficiency of terfenadine to fexofenadine was 90%. |
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| Keywords: | fexofenadine terfenadine microbial transformation |
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