西拉普利和氨氯地平治疗原发性高血压的临床对照研究

目的探讨西拉普利治疗原发性高血压的临床疗效和安全性。方法采用随机对照的方法，分别用西拉普利和氨氯地平治疗92例原发性高血压患者。观察药物治疗后8周内血压、心率的变化。结果服药8周后西拉普利组总有效率85．4％，收缩压和舒张压分别由治疗前的(20．4±1．8)kPa和(13．7±1．3)kPa降至治疗后的(17．4±1．7)kPa和(11．9±1．1)kPa；氨氯地平组总有效率为88．6％，收缩压和舒张压分别由治疗前的(20．5±1．7)kPa和(13．5±1．6)kPa降至治疗后的(17．3±1．7)kPa和(11．8±1．2)kPa,两组比较无统计学意义。患者用药后无严重的不良反应。结论西拉普利是一种安全和有效的治疗轻中度原发性高血压的药物。

The clinical comparative study of cilazapril and amilodipine in the treatment of essential hypertension

Objective To investigate the efficacy and safety of cilazapril in the treatrnent of essenia1 hypertension.Method Patientswere treated with cilazapril or amlodipine in randomized way. Results Effective rate of cilazapril group was 85.4% after8 weeksoftreat-mert with systolic and diastolic pressure decreased from (20.4+ 1.8)kPa and (13.7± 1.3)kPa to (17.4+ 1.7)kPa and (11.9± 1.1)kParespectively;While in amlodipine group, the total efficacy was 88.67% with systolic and diastolic pressure decreesed from (20.5+ 1.7)kPaand (13.5 + 1.6)kPa to (17.3 + 1.7)kPa and (11 .8± 1.2)kPa respectively. There were no significant difference between the two groups.No severe side effects were found in both groups. Conclusion Cilazapril is a safety and effective antihypertensive drug in patients with essen-tial hypertension.