| 宫颈鳞癌中Cyclin E的表达和HPV16感染的相关研究 |
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| 引用本文： | 李筱梅,陶银贵,郑英,胡卫红. 宫颈鳞癌中Cyclin E的表达和HPV16感染的相关研究[J]. 实用妇产科杂志, 2001, 17(2): 83-84 |
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| 作者姓名： | 李筱梅 陶银贵 郑英 胡卫红 |
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| 作者单位： | 河南医科大学第二附属医院,河南,郑州,450003 |
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| 摘 要： | 目的探讨Cyclin E在宫颈鳞状细胞癌中的表达及其与HPV16感染的关系.方法应用免疫组化S-P法对34例宫颈鳞状细胞癌组织进行Cyclin E与HPV16的检测,并与宫颈不典型增生和正常宫颈组织进行比较.结果正常宫颈组织无Cyclin E表达,宫颈不典型增生组织仅有少量袁达(11.11%),宫颈鳞状细胞癌有58.52%表达(P＜0.001),且与HPV16感染有明显相关性(P＜0.05).结论高危HPV感染是宫颈癌的重要病因,HPV感染通过多种途径改变了细胞的周期性调控,诱发细胞周期GI-S期检测点异常,引起细胞恶性增生,HPV感染与Cyclin E异常表达在宫颈癌的发生发展中起重要作用.
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| 关 键 词： | 细胞周期蛋白E 人乳头瘤病毒 宫颈鳞状细胞癌 |
| 文章编号： | 1003-6946(2001)02-083-02 |
| 修稿时间： | 2000-10-11 |
Expression of Cyclin E in Squamous Cervical Earcinoma and Relationship to Human Papillomavirus Infection |
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| LI Xiao mei,TAO Yin gui,ZHENG Ying,HU Wei hong. Expression of Cyclin E in Squamous Cervical Earcinoma and Relationship to Human Papillomavirus Infection[J]. Journal of Practical Obstetrics and Gynecology, 2001, 17(2): 83-84 |
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| Authors: | LI Xiao mei TAO Yin gui ZHENG Ying HU Wei hong |
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| Abstract: | Objectives:To investigate the expression of cyclin E in squamous cervical carcinoma (SCC) and relationship to human papillomavirus (HPV) infection.Metheds:The 34 cases of squamous cervical carcinoma were studied.Immunohistochemical staining was done for cyclin E,HPV16E7.Results:58.52%(14/34) of SCC tissues possessed the expression of cyclin E and only 11.11%(2/18) of cervical atypical hyperplasia and none of normal squamous epithelia tissues enabled to express cyclin E.HPV16E7 was found in 15 cases of SCC(55.83%). Significant correlation was found between cyclin E and HPV16 infection.Conlusions:High risk HPV infection induced abnormal cell cycle regulatory mechanisms.HPV infection and abnormal expression of cyclin E may be important in the development of cervical carinoma. |
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| Keywords: | Cyclin E Human papillomavirus Cervical carcinoma |
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