| 大鼠海马γ-氨基丁酸-A受体在生后发育中的表达 |
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| 引用本文： | 王晓亚,王增贤,王怀经,李振中. 大鼠海马γ-氨基丁酸-A受体在生后发育中的表达[J]. 解剖学杂志, 2006, 29(2): 200-202,208 |
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| 作者姓名： | 王晓亚 王增贤 王怀经 李振中 |
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| 作者单位： | 泰山医学院基础医学研究所,泰安,271000;山东大学医学院,济南 |
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| 摘 要： | 目的:研究大鼠生后发育过程中海马组织γ-氨基丁酸-A(GABA-A)受体的表达规律。方法:用免疫组织化学和PCR技术,检测不同年龄大鼠海马组织GABA-A受体及编码该受体的mRNA表达,并用图像分析方法进行定量研究。结果:大鼠海马组织在生后3 d已经出现GABA-A受体免疫反应,以后逐渐增强,到生后30 d达到最高值,海马各区GABA-A受体免疫反应强度没有显著的差别;编码GABA-A受体的mRNA表达也有类似的增龄性增多,但其表达高峰值提前到14 d。结论:生后大鼠海马GABA-A受体表达在一定时期内呈增龄性表达增强的趋势。
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| 关 键 词： | 海马 GABA-A受体 发育 大鼠 |
| 收稿时间： | 2004-04-14 |
| 修稿时间： | 2004-04-142005-10-26 |
Expression of GABA-A receptor in rat hippocampus during postnatal development |
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| WANG Xiao-Ya,WANG Zeng-Xian,WANG Huai-Jing,LI Zhen-Zhong. Expression of GABA-A receptor in rat hippocampus during postnatal development[J]. Chinese Journal of Anatomy, 2006, 29(2): 200-202,208 |
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| Authors: | WANG Xiao-Ya WANG Zeng-Xian WANG Huai-Jing LI Zhen-Zhong |
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| Affiliation: | Institute of Basic Medicine, Taishan Medical College, Taian 271000, China |
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| Abstract: | Objective: To study the expression of GABA-A receptor in rat hippocampus during postnatal development.Methods: Immunohistochemistry,PCR technique and the image analysis were used to study the expression of GABA-A receptor mRNA at various stages of the development.Results: GABA-A receptor was expressed early on the third postnatal day and increased gradually to its peak around the 30th day.There was no statistical difference in GABA-A receptor expression between various hippocampal areas.The expression of GABA-A receptor mRNA increased with age,but the peak of mRNA expression was on 14~(th) day,which was earlier than that of the receptor.Conclusion: During the postnatal development,the expression of GABA-A receptor and its mRNA tend to increase with the rat aging. |
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| Keywords: | hippocampus GABA-A receptor development rat |
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