急、慢性根尖周炎患牙根管内内毒素水平的分析测定

目的　比较急、慢性根尖周炎患牙根管内的内毒素水平并探讨内毒素与患牙尖周瘘管的关系。方法　选择急性根尖周炎、慢性根尖周炎根尖暗影直径<2 mm、根尖暗影直径>2 mm有瘘道和无瘘道的患牙各10例,采用产色基质鲎试剂法检测根管内内毒素含量。结果　慢性根尖周炎根尖暗影<2 mm的患牙,根管内内毒素水平明显低于急性根尖周炎及慢性根尖周炎根尖暗影>2 mm(有或无瘘道)的患牙,其差异有统计学意义(P<0·01)。结论　内毒素可能与尖周炎临床症状及根尖骨吸收程度密切相关。

Study on Endotoxin Levels of Acute and Chronic Periapical Periodontitis

Objective To compare the endotoxin levels between acute and chronic periapical periodontitis with different clinical symptoms.Methods 10 cases of acute periapical priodontitis(Group 1) ,10 cases of chronic periapical periodontitis(group 2, the diameter of apical radiolucency area was less than 2 mm),10 cases of chronic periapical periodontitis with sinus(group 3, the diameter of apical radiolucency area was greater than 2 mm), 10 cases of chronic periapical periodontitis without sinus (group 4, the diameter of apical radiolucency area was greater than 2 mm), were included in the study. Chromogenic substrate method of limulus amebocyte lysate(LAL) test was used to measure the endotoxin level.Results Endotoxin concentrations in group 2 were significantly lower than those in group 1, group 3 and group 4(P<0 01).Conclusion Endotoxin plays a very important role in the initiation and development of periapical periodotitis and is closely associated with clinical symptoms and apical radiolucency degree.