| 泻浊解毒通络法对糖尿病痛风模型大鼠血清FOXOL、VCAM-1及肾脏病理的影响 |
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| 引用本文： | 李中南,邢艳阳,邢宇婷,周媛媛,窦德梅. 泻浊解毒通络法对糖尿病痛风模型大鼠血清FOXOL、VCAM-1及肾脏病理的影响[J]. 上海中医药杂志, 2018, 52(11): 75-79 |
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| 作者姓名： | 李中南 邢艳阳 邢宇婷 周媛媛 窦德梅 |
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| 作者单位： | 安徽中医药大学第一附属医院内分泌科,安徽合肥,230031,安徽中医药大学研究生院,安徽合肥,230038,安徽中医药大学研究生院,安徽合肥,230038,安徽中医药大学研究生院,安徽合肥,230038,安徽中医药大学研究生院,安徽合肥,230038 |
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| 基金项目： | 国家中医临床研究基地业务建设科研专项(JDZX2012004) |
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| 摘 要： | 目的观察具有泻浊解毒通络作用的萆苓祛痛方对糖尿病痛风模型大鼠叉头转录因子(FOXOL)、细胞黏附分子(VCAM-1)及肾脏病理的影响。方法选择健康雄性SD大鼠50只,体质量(200±20) g,除正常组外,其余予高脂饲料喂养并联合小剂量链脲佐菌素35 mg/kg腹腔注射1次,以血糖≥16.7 mmol/L为糖尿病模型。4天后关节腔注射5%尿酸钠溶液1次,诱导痛风模型,模型成功后,萆苓祛痛方组、吲哚美辛组、吡格列酮组继续给药21 d,正常组、模型组予等量0.9%NaCl溶液,21 d后取血测定FOXOL、VCAM-1、Cys C,PG、UA、LDL-C,留取肾脏,观察肾脏病理变化。结果与正常组比较,模型组FOXOL、VCAM-1、Cys-C明显升高(P0.01);给药后,各药物组的上述指标显著降低(P0.01);萆苓祛痛方组上述指标优于吡格列酮组(P0.05,P0.01)。与正常组比较,模型组血糖、LDL-C明显升高(P0.01);灌胃后,药物组血糖、LDL-C显著下降(P0.01)。造模后,模型组血UA、SCr明显升高(P0.01),用药后各药物组血UA下降(P0.01);萆苓祛痛方组SCr下降(P0.05)。相关分析表明,高血糖与高尿酸血症呈相关性(r=0.42,P0.05)。病理报告示模型组大鼠肾小管间质充血肿胀,空泡样变性,有大量炎细胞浸润。予萆苓祛痛方后病变程度明显减低,肾小管见少量炎细胞浸润。结论具有泻浊解毒通络作用的萆苓祛痛方有良好的降糖、降尿酸、降LDL-C疗效;高血糖与高尿酸具有相关性,可明显下调FOXOL、VCAM-1、Cys-C的高表达,减轻炎症因子对肾脏病理的影响。
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| 关 键 词： | 泻浊解毒通络法 萆苓祛痛方 糖尿病痛风大鼠 FOXOL VCAM-1 肾脏病理 |
| 收稿时间： | 2018-08-22 |
Effects of therapy of eliminating turbid, detoxification and dredging collaterals on serum FOXOL and VCAM-1 and renal pathology in model rat of diabetic gout |
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| LI Zhongnan,XING Yanyang,XING Yuting,ZHOU Yuanyuan and DOU Demei. Effects of therapy of eliminating turbid, detoxification and dredging collaterals on serum FOXOL and VCAM-1 and renal pathology in model rat of diabetic gout[J]. Shanghai Journal of Traditional Chinese Medicine, 2018, 52(11): 75-79 |
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| Authors: | LI Zhongnan XING Yanyang XING Yuting ZHOU Yuanyuan DOU Demei |
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| Affiliation: | Department of Endocrinology, First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230031, China,Graduate School, Anhui University of Traditional Chinese Medicine, Hefei 230038, China,Graduate School, Anhui University of Traditional Chinese Medicine, Hefei 230038, China,Graduate School, Anhui University of Traditional Chinese Medicine, Hefei 230038, China and Graduate School, Anhui University of Traditional Chinese Medicine, Hefei 230038, China |
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