c-erbB-2基因表达水平与结直肠癌的预后

目的：c-erbB-2基因在结直肠癌中的表达水平及其与预后的关系。方法利用免疫组化LSAB法检测173例结直肠癌组织中c-erbB-2基因表达水平，并结合长期随访资料进行分析，结果：c-erbB-2基因主要为胞浆内及细胞膜表达，癌组织阳性率52％。c-erbB-2表达阴性组1，3，5，10，年生存率分别为98．7％、92．4％、87．1％和84．1％，弱阳性组分别为94．5％、76．1％、72．3％和68．3％，强阳性组分别为91．0％、43．5％、36．8％和23．4％，差异有显著性（P＜0．001）。Cox回归多因素分析提示，c-erbB-2表达水是死亡的危险因素，即表达水平越高，预后越差。结论c-erbB-2表达水平可作为临床上预测结直肠癌预后的可靠指标，是影响结肠癌预后的独立因素。

Expression level of c-erbB-2 protein correlates with the prognosis of patients with colorectal cancer

OBJECTIVE: To study the expression level of c-erbB-2 gene in colorectal cancer and its correlation to prognosis. METHODS: In 173 colorectal carcinoma patients, c-erbB-2 protein was examined immunohistochemically and patients' prognosis was evaluated by retrospective analysis combined with follow-up data. RESULTS: The immunohistochemical staining of c-erbB-2 protein was found in the cytoplasm and membrane with a positive rate of 52% in tumor tissue. The 1-, 3-, 5- and 10-year survival rate of patients with negative c-erbB-2 expression was 98.7%, 92.4%, 87.1% and 84.1% respectively; that of the patients with weakly positive c-erbB-2 expression was 94.5%, 76.1%, 72.3% and 68.3%, respectively. In contrast, that of patients with strongly positive c-erbB-2 expression was 91.0%, 43.5%, 36.8% and 23.4%, respectively. The survival rates among the three groups of patients were statistically different. Multivariate survival analysis by Cox regression model showed that c-erbB-2 expression level was a risky prognostic factor for colorectal cancer. CONCLUSION: The expression level of c-erbB-2 protein is an independent prognostic factor in colorectal carcinoma.