老年缺血性卒中患者的认知功能与代谢综合征及炎症反应的关系

目的探讨老年缺血性脑卒中患者的认知功能与代谢综合征(MS)及炎症反应的关系。方法94例缺血性脑卒中患者分为认知功能正常组(NC,34例),轻度血管性认知功能障碍组(MVCI,37例),血管性痴呆组(VD,23例);分别测定其空腹血糖(FBG)、空腹胰岛素(FI NS)、C反应蛋白(CRP)及血压、血脂、体质量指数(BMI),观察各组代谢综合征的发生率,检测炎症标记物,进行对比研究。结果NC组、MVCI组、VD组代谢综合征的发生率(12、33、49%,P<0.05)显著递增;CRP:MVCI组(1.4±0.5)mg/L与VD组(2.1±0.7)mg/L高于NC组(0.8±0.4)mg/L(P<0.05);CRP与胰岛素抵抗指数显著相关(r=0.39,P<0.05)。结论MS及炎症反应是老年缺血性脑卒中患者认知功能下降的重要危险因素。

The metabolic syndrome,inflammation,and risk of cognitive decline in elderly patients with ischemic stroke

Objective To study the risk of cognitive decline in elderly patients with ischemic stroke and the metabolic syndrome,inflammation.Methods Ninty-four elderly patients with ischemic stroke were divided into normal cognition(NC) group(34 cases),mild vascular cognitive impairment(MVCI) group(37 cases) and vascular disease(VD) group(23 cases);Their fasting blood glucose(FBG),insulin levels before breakfast,serum C reactive protein(CRP) and blood pressure,lipids,body mass index(BMI) were assessed.The incidence of metabolic syndrome and the marker of inflammation of each group were observed and compared.Results The prevalence of metabolic syndrome(12,33,49% respectively) had a progressive increase among NC group,MVCI group and VD group(P<0.05),The similar results were observed in the detection of CRP(P<0.05).Conclusion MS and inflammation are important risk factors for the cognitive impairment in elderly patients with ischemic stroke.