| 川芎嗪对博菜霉素致肺间质纤维化大鼠MMP-9表达的影响 |
| |
| 引用本文： | 王增欣,段斐,刘颖,孙晓芳,李少春,崔娜.川芎嗪对博菜霉素致肺间质纤维化大鼠MMP-9表达的影响[J].中国中医药咨讯,2010,2(17):252-253. |
| |
| 作者姓名： | 王增欣 段斐 刘颖 孙晓芳 李少春 崔娜 |
| |
| 作者单位： | 河北大学基础医学院,河北,保定,071000 |
| |
| 基金项目： | 河北省科技攻关课题，河北省保定市科技局资助课题 |
| |
| 摘 要： | 目的研究川芎嗪对博莱霉素致肺间质纤维化大鼠MMP-9表达的影响。方法选SD雄性大鼠40只，随机分为4组即正常组、模型组、阳性药物对照组及川芎嗪组，每组10只。于28d麻醉后取肺组织，采用免疫组化和western blot的方法检测MMP-9的表达。结果模型组MMP-9表达上调，川芎嗪组表达降低，表明川芎嗪可以降低博莱霉素所致肺纤维化大鼠MMP-9的表达。结论通过降低MMP-9的表达，可能是川芎嗪发挥抗肺纤维化作用的途径之一。
|
| 关 键 词： | 川芎嗪 肺间质纤维化 MMP－9 |
TMP on bleomycin-induced pulmonary fibrosis in rats the expression of MMP-9 |
| |
| Institution: | Wang Zeng-xin ,Sun Xiaofang,Li Shaochun,et al (Hebei University, Hebei,Baoding, 071000) |
| |
| Abstract: | Objective： To study the TMP on bleomycin-induced pulmonary, fibrosis in rats the expression of MMP-9. Methods： 40 SD male ＇rats. Randomly divided into sham operation group, model group, positive control group and TMP group, a total of 4 groups of 10 each. 28 days after anesthesia in lung tissues were harvested for immunobistochemical staining and western blot MMP-9. Results： MMP-9 upregulation in the untreated group, TMP group was decreased, indicating that TMP can reduce bleomycin-induced pulmonary fibrasis in rats the expression of MMP-9. Conclusion： By reducing the expression of MMP-9 may play an anti-TMP one of the ways the role of pulmonary fibrosis. |
| |
| Keywords: | MMP-9 |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
