彩色多普勒超声对中晚期青光眼患者眼动脉血流速度的测定

目的了解中、晚期青光眼患者眼动脉血流情况及血管因素在中、晚期青光眼患者视功能损害机制中的作用。方法采用彩色多普勒超声检查仪测定１５６例中、晚期青光眼患者的眼动脉血流速度，并与正常组７５例的有关参数值进行比较。结果正常组：平均最大收缩期血流速度（ｐｅａｋｓｙｓ－ｔｏｌｉｃｖｅｌｏｃｉｔｙ，ＰＳＶ）为３５．９８±９．１３ｃｍ／ｓ，舒张期眼动脉血流速度（ｅｎｄｄｉａｓｔｏｌｉｃｖｅｌｏｃｉｔｙ，ＥＤＶ）为１１．９８±３．９０ｃｍ／ｓ。开角型青光眼（ｐｒｉｍａｒｙｏｐｅｎａｎｇｌｅｇｌａｕｃｏｍａ，ＰＯＡＧ）组：ＰＳＶ为２４．１３±４．６５ｃｍ／ｓ，ＥＤＶ为７．１０±１．８５ｃｍ／ｓ，闭角型青光眼（ｐｒｉｍａｒｙｃｌｏｓｅａｎｇｌｅｇｌａｕｃｏｍａ，ＰＣＡＧ）组：ＰＳＶ为２２．８９±５．４３ｃｍ／ｓ，ＥＤＶ为７．０６±１．９２ｃｍ／ｓ。各组间ＰＳＶ与ＥＤＶ比较：ＰＯＡＧ组与ＰＣＡＧ组间差异无显著性（Ｐ＞０．０５），青光眼组与正常组间差异有非常显著性（Ｐ＜０．０１）。结论中、晚期青光眼患者因眼动脉血流速度下降明显，导致局部血液循环障碍。青光眼患者的视功能损害与视神经的血供不足关系密切。

Analysis of blood flow in ophthalmic arteries in patients with middle and late stages of glaucoma with Doppler sonography

OBJECTIVE: To understand the actual blood flow in cases with middle and late stages of glaucoma and the role of vascular factor in the deterioration of visual function in such patients. METHODS: The blood flow in ophthalmic arteries was determined with color Doppler sonography (CDS) in 156 cases of patients with middle and late stages of glaucoma as well as in 75 cases of normal individuals as controls. RESULTS: The average peak systolic velocity (PSV) and end diastolic velocity (EDV) of ophthalmic artery in normal control are 35.98 +/- 9.13 cm/s and 11.98 +/- 3.90 cm/s; the PSV and EDV in primary open-angle glaucoma (POAG) group are 24.13 +/- 4.65 cm/s and 7.10 +/- 1.85 cm/s; and in primary close-angle glaucoma (PCAG) group are 22.89 +/- 5.43 cm/s and 7.06 +/- 1.92 cm/s, respectively. No significant difference was found between POAG group and PCAG group (P > 0.05). However, significant differences were shown between normal group and patients with glaucoma for both PSV and EDV (P < 0.01). CONCLUSION: The blood flow in ophthalmic arteries in patients with middle and late stages of glaucoma decreases significantly and the disorder in local blood circulation is evident, that is highly related to the deterioration of visual function and supports the vascular factor theory in the pathogenesis of glaucoma.