鼻咽癌患者血清瘦素水平的相关性研究

目的探讨鼻咽癌患者血清瘦素（Leptin）、体质指数（BMI）、甘油三酯（TG）、总胆同醇（TC）的含量及变化关系。方法随机收集鼻咽癌患者50例，健康对照组42例的血清，采用放射免疫法分析法测定瘦素水平，并进行体质指数的测量与计算；TG、TC由自动生化仪测定，采用SPSS软件包进行统计学处理。结果健康对照组的BMI为（23．65±3．32）kg／m^2，高于鼻咽癌组患者[（21．12±2．86）kg／m^2]，t=-3．21，P=0．002，健康对照组的Leptin为（10．205±9．319）ng/ml，高于鼻咽癌组患者[（4．375±4．367）ng/ml]，组内比较P〈0．05，组间比较P〈0．05，Leptin与BMI、TG、TC呈正相关系。结论鼻咽癌患者的Leptin和BMI降低，而且Leptin与BMI、TG、TC呈正相关系。

Relationship of leptin with body mass index,triglyceride,and total cholesterol in patients with nasopharyngeal carcinoma

Objective To investigate the correlation of serum leptin with body mass index (BMI),triglyceride(TG),and total cholesterol(TC)in patients with nasopharyngeal carcinoma. Methods A total of 50 serum specimens from patients with nasopharyngeal carcinoma and 42samples from healthy subjects were collected.Levels of leptin were detected by radioimmunoassay,so were levels of TG and TC by an automatic biochemical analyzer.BMI was determined.The data were analyzed using the SPSS software.Results BMI values and leptin levels were obviously higher in the healthy subjects than in patients with nasopharyngeal carcinoma[(23.65±3.32)kg/m2 vs.(21.12±2.86)kg/m2 and(10.205±9.319)ng/ml vs.(4.375±4.367)ng/ml;t=-3.21 P=0.002,and P ＜0.05].Leptin was positively related with BMI.TG,and TC.Conclusions Leptin levels and BMI values decrease in patients with nasopharyngeal carcinoma.Leptin is positively related with BMI,TG,and TC.