A novel evaluation system of metastatic potential of oral squamous cell carcinoma according to the histopathological and histochemical grading |
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Authors: | S Mori M Nose H Morikawa A Sato T Saito S-T Song N Tanda T Teshima |
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Institution: | aDepartment of Oral and Maxillofacial Surgery II, Tohoku University School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan;bDepartment of Pathology, Ehime University School of Medicine, Ehime, Japan |
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Abstract: | We established a new evaluation system for metastatic potential of oral squamous cell carcinoma (SCC), utilizing a combined examination of histopathological grades of the carcinomas based on cell differentiation and invasive mode according to Yamamoto’s criteria, and the cellular expressions of CD44, E-cadherin (E-cad), heparan sulfate glycosaminoglycan (HS-GAG) and Phaseolus vulgaris leukoagglutinin (L-PHA)-binding oligosaccharides on the carcinomas. Histochemical patterns of expression of these markers were classified into positive (++), weakly positive (+), and negative (−). The histopathological grades and the histochemical patterns of the SCC were estimated on a 0–2 point scale, i.e. point 2 for poorly differentiated, mode 4D, CD44++, E-cad−, HS-GAG++, or L-PHA++; point 1 for moderately differentiated, mode 4C, CD44+, E-cad+, HS-GAG+, or L-PHA+; and point 0 for well differentiated, mode 1, mode 2, mode 3, CD44−, E-cad++, HS-GAG−, or L-PHA−. As a result, incidence of metastasis in the cases with a total score of more than 6 (62.8%) was significantly higher than that with a total score of less than 5 (9.3%). This evaluation system will yield useful information concerning the prognosis of patients with oral SCC. |
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Keywords: | CD44 E-cadherin Heparan sulfate glycosaminoglycan Phaseolus vulgaris leukoagglutinin-binding oligosaccharides Squamous cell carcinoma Metastasis |
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