Review: Multiple system atrophy: emerging targets for interventional therapies |
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Authors: | N Stefanova G K Wenning |
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Institution: | Division of Neurobiology, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria |
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Abstract: | Multiple system atrophy (MSA) is a fatal orphan neurodegenerative disorder that manifests with rapidly progressive autonomic and motor dysfunction. The disease is characterized by the accumulation of α‐synuclein fibrils in oligodendrocytes that form glial cytoplasmic inclusions, a neuropathological hallmark and central player in the pathogenesis of MSA. Here, we summarize the current knowledge on the etiopathogenesis and neuropathology of MSA. We discuss the role of α‐synuclein pathology, microglial activation, oligodendroglial dysfunction and putative cell death mechanisms as candidate therapeutic targets in MSA. |
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Keywords: | α ‐synuclein aetiology clinical trial multiple system atrophy neuropathology pathogenesis |
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