| 基质金属蛋白酶-9在甲状腺癌中的表达及临床意义 |
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| 引用本文： | 张慧芹,刘阁玲.基质金属蛋白酶-9在甲状腺癌中的表达及临床意义[J].医学理论与实践,2005,18(4):389-390. |
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| 作者姓名： | 张慧芹 刘阁玲 |
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| 作者单位： | 唐山工人医院内分泌科,063000 |
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| 摘 要： | 目的:研究基质金属蛋白酶- 9(MMP - 9)的表达与甲状腺癌的临床分期和淋巴结转移的关系,探讨其在甲状腺癌发生发展、侵袭和转移中的机制。方法:采用免疫组织化学SP法检测5 0例甲状腺癌标本及2 0例癌旁正常甲状腺组织中MMP - 9蛋白的表达。结果:甲状腺癌中MMP - 9的表达显著高于癌旁正常组织,与甲状腺癌的临床分期和淋巴结转移密切相关。结论:MMP - 9在甲状腺癌的侵袭转移中发挥关键作用,其过度表达可作为甲状腺癌患者的预后指标
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| 关 键 词： | 甲状腺癌 免疫组化 基质金属蛋白酶(MMP-9) |
| 文章编号： | 1001-7585(2005)04-0389-02 |
| 修稿时间： | 2004年11月7日 |
Clinical Significance of Expression of MMP-9 in Human Thyroid Carcinoma |
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| ZHANG Huiqin,LIU Geling.Clinical Significance of Expression of MMP-9 in Human Thyroid Carcinoma[J].The Journal of Medical Theory and Practice,2005,18(4):389-390. |
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| Authors: | ZHANG Huiqin LIU Geling |
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| Institution: | ZHANG Huiqin,LIU Geling.Department of Endocrinology,Tangshan Worker's Hospital,Hebei Province 063000 |
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| Abstract: | Objective: To investigate the correlation between the expression of MMP-9 and histological feature,clinical stage, lymph node metastasis in thyroid carcinoma. Methods: The SP immunohistochemical method was employed to determine the expression of MMP-9 in 50 cases of thyroid carcinoma and 20 cases of para-tumorous tissue. Results: The expression of MMP-9 in thyroid carcinoma was remarkablely higher than that in the para-tumorous tissue,the result was uncorrelated with histological feature,but correlated with clinical stage and lymph node metastasis.Conclusions: The expression of MMP-9 is associated with invasion and metastasis of thyroid carcinoma,which may serve as prognosis indexes of thyroid carcinoma. |
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| Keywords: | Thyroid carcinoma Immunohistochemistry MMP-9 |
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