抗Jo-1抗体综合征患者临床免疫学特征

目的 探讨抗Jo-1抗体综合征患者的临床免疫学特征与抗Jo-1抗体相关性。方法 分析36例抗Jo-1抗体阳性的多发性肌炎／皮肌炎（PM／DM）的首发症状、临床及免疫学特征，并与阴性组70例进行比较。结果 抗Jo-1抗体阳性组呼吸系统表现起病者11例（30．1％），典型皮疹和／或肌痛、肌无力起病者仅6例（16．7%），与抗Jo-1抗体阴性组比较，差异显著（P〈0．05）；阳性组出现肺间质病变（ILD）、肺部感染和多关节炎／关节痛分别为23例（63．9%）、28例（77．8％）和29例（80．6％），与抗Jo-1抗体阴性组比较，差异显著（P〈0．05）。阳性组出现吞咽困难6例（16．7%），阴性组21例（30．0％）；阳性组抗核抗体（ANA）、抗心磷脂抗体（ACL）和抗SSA／SSB抗体检出率分别为21例（61．6％）、16例（44．4％）和18例（50．O％），与阴性组比较，差异显著（P〈o．05）。结论 抗Jo-1抗体综合征以呼吸道症状起病较多，而典型肌炎起病者较少，伴发ILD、肺部感染及多关节炎／关节痛表现突出，出现吞咽困难的概率低，ANA、ACL及抗SSA／SSB阳性率较高。

Clinical and immunological features of anti-Jo-1 syndrome

Objective To investigate the clinical and immunological features of anti-Jo-1(syndrome) and its relationship with anti-Jo-1 antibody.Methods The data of 36 polymyositis(PM)/(dermatomyositis)(DM) patients with anti-Jo antibody were reviewed restrospectively.The initial symptom,clinical and immunological characteristics were studied.Results Eleven(30.1%) patients with anti-Jo antibody developed lung impairment before the onset of PM/DM,and only 6(16.7%) patients had the typical rash,and/or myalgia and muscle weakness as an initial symptome.The percentage of patients with interstitial pneumonia was 63.9%,with lung infections 77.8%,with arthritis 80.6%,with ANA 61.6%,with ACA 44.4%,and with SSA/SSB 50.0% in antiJo-1 antibody positive group.Conclusion(In patients) with anti-Jo-1 syndrome,the lung impairment in early phase of the disease is more common.The incidence of interstitial pneumonia,lung infection,arthritis,ANA,ACA and anti-SSA/SSB are significantly increased in anti-Jo-1 antibody positive patients,while the incidence of dysphagia is significantly increased in anti-Jo-1 antibody negative patients.