黄芪多糖联合达英-35对多囊卵巢综合征患者胰岛素抵抗、雄激素及脂代谢的影响

目的：探讨黄芪多糖和达英-35联合应用对多囊卵巢综合征（PCOS）胰岛素抵抗、雄激素水平及脂代谢的影响。方法：对32例PCOS患者联合应用黄芪多糖和达英-35共3个月，观察治疗前后血性激素、胰岛素敏感性及血脂的改变。结果：治疗后患者血清空腹胰岛素水平、LH／FsH比值、T、A、DHEAS均显著降低（P〈0．01），胰岛素敏感指数显著升高，血T—CHO、Lp（a）降低（P〈0．01），HDL—C显著升高，TG也有轻度降低，差异具有统计学意义（P〈0．05）。结论：黄芪多糖联合达英-35可有效改善PCOS患者胰岛素抵抗和高雄激素状态及血脂代谢，可为PCOS治疗的又一选择。

Influence of Astragalus POlysaccharides Plus Diane-35 on Insulin Resistance and Androgen Levels and Lipid Metabolism of Patients with Polycystic Ovary Syndrome

Objective：To investigate the effection of astragalus polysaccharides plus diane-35 on insulin resistance.androgen levels and lipid metabolism of patients with polycystic ovary syndrome （PCOS）. Methods： 32 women with PCOS participated in the study and were administered with combined application of astragalus polysaccharides and diane-35 for 3 months. Sex hormones ,insulin sensitivity and blood lipid were evaluated before and after the therapy. Results ： After the treatment, fasting serum insulin levels, LH/FSH ratio, T, A, DHEAS, blood T-CHO and Lp （a） decreased significantly（P〈0.01） ,in the opposite ,insulin sensitivity index and HDL-C increased significantly,while TG has lightly reduced,and the difference was significant（P〈0. 05）. Conelusion：Astragalus polysaecharides plus diane-35 can be effective in improving insulin resistance,high androgen hormone status and lipid metabolism in patients with PCOS,and it may be alternative for PCOS.