Development and perspective of current Brazilian studies on the epidemiology of childhood leukemia |
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| Authors: | Maria S. Pombo de Oliveira Sergio Koifman Gisele M. Vasconcelos Mariana Emerenciano Cristiane de Oliveira Novaes |
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| Affiliation: | 1. Centre for Haematology, Imperial College London, UK;2. MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, UK;1. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21224;2. The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21224;1. University of Ljubljana, Faculty of Medicine, Institute of Biochemistry, Pharmacogenetics Laboratory, Vrazov trg 2, 1000 Ljubljana, Slovenia;2. University Medical Center, University Children''s Hospital, Oncology and Haematology Unit, Bohori?eva 20, Ljubljana, Slovenia;3. University Medical Center, University Children''s Hospital, Center for Medical Genetics, Vrazov trg 1, Ljubljana, Slovenia |
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| Abstract: | In this concise report, we describe the history and evolution of childhood acute leukemia studies in Brazil, and the application if key biomarkers for clinical trials and epidemiological studies over the past 8 years. Highlights of each ongoing study are summarized. A Brazilian network integrating hospitals and scientific institutions from all country regions has been established. This organization is made possible through informatics and computer networking, and the standardization of pathological reviews including immunophenotyping and molecular characterization of childhood leukemias. The unique characteristics of the Brazilian population combined with a large clinical and epidemiologic framework for patient ascertainment has enabled large-scale epidemiological studies on childhood leukemia in Brazil. |
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