Influence of chronic fluorosis on protein kinase Cβ/ p66shc signal pathway in the brain of rats

<正>Objective To investigate the influence of chronic fluorosis on protein kinase Cβ(PKCβ)p66shc signal pathway in the brain of rats,and reveal the molecular mechanism of brain damage.Methods According to body weight by the random number table method thirty SD rats were divided into three groups of 10 each(half females and half males),the normal control groupless than0.5 mg/L of fluorine(prepared with Na F)in drinking