1~24月婴幼儿胰岛素样生长因子-1水平及与生长发育的关系

目的：分析1~24月龄婴幼儿血清胰岛素样生长因子-1（IGF-1）水平及其与生长发育的关系。方法：525名健康婴幼儿入选本研究（早产儿125名，足月儿400名），测量体重/身长，酶联免疫吸附法检测血清IGF-1水平。结果：早产组婴儿期血清IGF-1水平在生后1.5月为最低（86±60 ng/mL），此后一直维持较高水平，生后4~12月显著高于足月组。足月组婴儿期血清IGF-1水平在生后1.5月为最高(116±52 ng/mL)，此后缓慢下降，生后8月时降至最低（69±58 ng/mL）。不论是早产儿还是足月儿体重/身长SDS与血清IGF-I水平均存在着正相关关系。结论：血清IGF-1水平均与婴幼儿期生长发育速度密切相关。［中国当代儿科杂志，2010，12（6）：459-461］

Insulin-like growth factor 1 levels and their association with growth and development in infants aged 1-24 months

Objective To study serum insulin-like growth factor 1(IGF-1)levels and their association with growth and development in infants aged 1-24 mouths.Methods A total of 525 healthy infants(125 preterm,400 term)were enrolled.Serum IGF-1 levels were measured using ELISA 1.5,4,6,8,12,18 and 24 months after birth.The body weight and body length were simultaneously measured.Results Serum IGF-1 levels were the lowest in preterm infants 1.5 months after birth(86± 60 ng/mL).Thereafter,serum IGF-1 levels increased,and were significantly higher than those in term infants between 4 and 12 months after birth.Serum IGF-1 levels in term infants were the highest(116±52 ng/mL)1.5 months after birth during their life of 12 months old.Thereafter,serum IGF-1 levels decreased and reached to a nadir(69±58 ng/mL)8 months after birth.IGF-I levels were positively correlated with the weight and the height(SDS)in both preterm and term infants.Conclusions Serum IGF-1 levels are closely associated with growth and development in infants.