非诺贝特和吡格列酮对肥胖大鼠血清内脏脂肪素的影响

目的观察非诺贝特和吡格列酮对肥胖大鼠血清内脏脂肪素（visfatin）的影响。方法内脏脂肪素75只SD雄性大鼠随机分为5组：F、P、FP、HF、NC组，各15只，前4组予高脂饮食，NC组予普通饲料，12周后F、P、FP组分别予非诺贝特30mg·kg^-1·d^-1、吡格列酮10mg·kg^-1·d^-1、两药联合灌胃，HF和NC组予相应溶剂灌胃，均灌胃4周，检测血清内脏脂肪素和生化指标。结果与NC组相比，HF组大鼠体重、FFA、FPG、Ins、HOMA—IR和血清内脏脂肪素水平均明显增高（P〈0．05）；与HF组相比，F、P和FP组大鼠FFA、HOMA—IR、内脏脂肪素均降低（P〈0．05）。F、FP组体重降低，与P、HF组有统计学差异（P〈0．05）。结论肥胖大鼠出现胰岛素抵抗和血清内脏脂肪素升高，非诺贝特和（或）吡格列酮能降低FFA，提高胰岛素敏感性，降低血清内脏脂肪素。

Effects of pioglitazone and fenofibrate on level of serum visfatin in obese rats

Objective To observe the effects of fenofibrate and pioglitazone on levels of serum visfatin in obese rats. Methods 75 SD male rats were randomly divided into five groups： F, P, FP, HF, NC group, 15 rats in each group. NC group were fed with standard food and the others with high-fat diet. After 12 weeks, F, P, FP groups were treated with fenofibrate 30mg/kg, pioglitazone 10mg/kg, and the two drugs daily for 4 weeks respectively. HF and NC groups were treated with homologous solvent. Serum visfatin and biochemical data were detected. Results The levels of body weight, FFA, FPG, INS,HOMA IR and visfatin were elevated significantly in HF versus NC group （P〈 0. 05）. Compared with HF group, FFA, HOMA-IR and visfatin decreased markedly in F,P,FP groups（P〈0.05）. Body weight of rats in F and FP groups was reduced obviously compared with P and HF groups （P〈0.05）. Conclusions The insulin resistance and increase of serum visfatin are characteristics of obese rats. Fenofibrate and/or pioglitazone can reduce FFA, increase insulin sensitivity and decrease serum visfatin.