| BDNF基因多态性在重性抑郁障碍患者与健康人群的对照研究 |
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| 引用本文： | 张璐璐,彭建玲,郑洪波.BDNF基因多态性在重性抑郁障碍患者与健康人群的对照研究[J].广州医药,2011,42(1):9-12. |
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| 作者姓名： | 张璐璐 彭建玲 郑洪波 |
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| 作者单位： | 广州市精神病医院精神科,510370 |
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| 基金项目： | 广州市医药卫生科技项目(2008-YB-105) |
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| 摘 要： | 目的 探讨脑源性神经营养因子(BDNF)基因Val66Met多态性与重性抑郁障碍的关系.方法 以100例重性抑郁障碍患者(研究组)与100例健康志愿者(对照组)为研究对象,检测BDNF基因Val66Met多态性.结果 研究组Met等位基因频率高于对照组(χ2=5.293),Val等位基因频率低于对照组(χ2=5.293...
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| 关 键 词： | 脑源性神经营养因子 抑郁障碍 基因 多态性 |
Control study on brain-derived neurotrophic factor gene polymorphism between major depressive disorder and healthy people |
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| Zhang Lulu,Peng Jianling,Zheng Hongbo.Control study on brain-derived neurotrophic factor gene polymorphism between major depressive disorder and healthy people[J].Guangzhou Medical Journal,2011,42(1):9-12. |
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| Authors: | Zhang Lulu Peng Jianling Zheng Hongbo |
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| Institution: | Zhang Lulu,Peng Jianling,Zheng Hongbo.Guangzhou Psychiatric Hospital,Guangzhou 510370,China |
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| Abstract: | Objective To investigate the relationship between brain-derived neurotrophic factor(BDNF)gene Val66Met polymorphism and major depressive disorder. Methods 100 patients with major depressive disorder and 100 healthy volunteers were included in the research as study group and control group respectively.BDNF gene polymorphism was detected. Results Met allele frequency in study group was higher than that in control group(χ2=5.293),but Val allele was lower(χ2=5.293).All differences were statistically significant(P<0.05).Controlling gender factor,depression relative risk of individuals carrying Met allele increased 1 times as much as carrying Val allele(β=0.733,P=0.021,OR=2.082,95%CI:1.116～3.884). Conclusion BDNF gene Val66Met polymorphism is correlated with morbility of depression,Met allele is regarded as risk factor of disease. |
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| Keywords: | Brain-derived neurotrophic factor Depression Gene Polymorphism |
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