| 止消通脉宁对糖尿病大鼠肾小球形态改变的影响及定量分析 |
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| 引用本文： | 王耀献,原爱红,赵雁,魏民,吕仁和.止消通脉宁对糖尿病大鼠肾小球形态改变的影响及定量分析[J].北京中医药大学学报,1999,22(4):3. |
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| 作者姓名： | 王耀献 原爱红 赵雁 魏民 吕仁和 |
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| 作者单位： | 北京中医药大学,北京100029 |
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| 基金项目： | “九五”国家科技攻关项目 |
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| 摘 要： | 采用链脲佐菌素（ＳＴＺ）腹腔注射建立糖尿病大鼠模型，观察中药复方止消通脉宁对其肾小球形态学的影响。结果表明：与正常对照组相比，各组糖尿病大鼠肾小球毛细血管基底膜厚度（ＧＢＭＷ）、系膜区平均面积［Ａ（Ｍ）］、肾小球平均截面积［Ａ（Ｇ）］、肾小球直径［Ｄ（Ｇ）］和肾小球体积［Ｖ（Ｇ）］均显著增加，其中模型组最为明显，西药组次之，中药组最轻。控制肾脏肥大、减轻ＧＢＭ增厚以及抑制系膜增生，是止消通脉宁治疗糖尿病肾病的主要作用机制。
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| 关 键 词： | 止消通脉宁 实验性糖尿病 肾小球形态 定量分析 大鼠 |
| 修稿时间： | 1998-11-20 |
A Quantitative Analysis on Effects of ZhiXiaoTongMaiNing on Glomerular Morphologic Changes of Diabetes Rat |
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| Wang Yaoxian.A Quantitative Analysis on Effects of ZhiXiaoTongMaiNing on Glomerular Morphologic Changes of Diabetes Rat[J].Journal of Beijing University of Traditional Chinese Medicine,1999,22(4):3. |
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| Authors: | Wang Yaoxian |
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| Abstract: | A diabetes rat model was establisbed by intraperitoneal injection of streptozotocin. Observe the effects of Zhixiaotongmaining on the glomerular morphologic changes. The results show that: Compared to the normal control group, there are markedly increase of glomerular basement membrane width (GBMW), average mesentery area , average glomeruluar sectional area, , glomerular diameter and volume in the deabetes group, among which the model group is most remarkable, the western medicine group is second to it and the Chinese medicine group is the lest remarkable. So controlling nephrohypertrophy, modifying GBM widening and inhibiting mesentery proliferation are the main mechanism of action. |
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| Keywords: | Zhixiaotongmaining Experimental diabetes Glomerular morphology Quantitative analysis Rats |
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